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This article is original by Translational Medicine Network.
Please indicate the source for reprinting.
Author: Yun Introduction: Many studies have proved the link between the gut microbiome and disease, but whether the gut and breast microbiome mediates the effect of diet on breast cancer influences? The scientist gave the answer! Breast cancer is one of the most common malignant tumors in women worldwide, and it is showing a rapid growth trend
.
Its incidence rate ranks first among female malignant tumors all year round, so it is often called the "pink killer"! Even more frightening is that according to the latest global cancer burden data released by the International Agency for Research on Cancer (IARC) of the World Health Organization in 2020, the number of new cases of breast cancer worldwide is expected to reach 2.
26 million in 2020, surpassing the 2.
2 million cases of lung cancer.
Replace lung cancer and become the world's largest cancer
.
Existing reports have shown that intestinal microbes can promote the occurrence of breast cancer by changing the level of systemic estrogen
.
This is generally considered to be a possible mechanism of breast cancer caused by a high-fat, low-fiber diet and antibiotic exposure
.
Later, researchers discovered a unique microbiome in breast milk and breast tissue
.
But so far, there have been few studies on the differences in the microbiota of breast tissue between breast cancer patients and healthy people.
Therefore, researchers have focused their attention on the study of intestinal microbes
.
Recently, researchers demonstrated that dietary patterns regulate the mammary gland microbiota
.
An important and unresolved question is whether the microbiome of the gut and breast mediates the effect of diet on breast cancer? To solve this problem, the researchers performed fecal transplants between mice on a controlled diet and a high-fat diet (HFD), and recorded the development of breast tumors
.
The research was published in the journal Cancer Research, entitled "Diet alters entero-mammary signaling to regulate the breast microbiome and tumorigenesis"
.
Researchers found that obesity and poor diet often complement each other, and together change metabolic signals, thereby affecting the risk of breast cancer
.
Many studies have proven the link between the gut microbiome and breast cancer.
For example, in January 2021, researchers found that when enterotoxigenic Bacteroides fragilis (ETBF) was introduced into the intestines or mammary ducts of mice , It can always induce the growth and metastasis of tumor cells
.
On June 13, 2019, a new study from the University of Virginia Cancer Center showed that an unhealthy, inflamed intestine can make breast cancer more aggressive and spread to other parts of the body more quickly
.
In this study, researchers used a multi-pronged approach to study animal models and breast cancer patients to understand the relationship between the microbiome, diet, and cancer risk
.
Now, new research by scientists at Wake Forest School of Medicine shows that diets that include fish oil supplements can not only change the breast microbiome, but also breast cancer
.
Mice susceptible to breast cancer were first fed a high-fat or low-fat diet
.
The researchers observed that mice on a high-fat diet had more tumors and tumors grew faster and larger in shape than mice on a low-fat diet
.
The researchers then performed a stool transplant to study the microbiome
.
Mice on a low-fat diet received a high-fat diet microbiome transplantation, and mice on a high-fat diet received a low-fat diet microbiome transplant
.
To their surprise, the researchers observed that mice that ate a low-fat diet and received a high-fat diet microbiome had roughly the same number of breast tumors as mice that ate a high-fat diet
.
Dr.
Katherine L.
Cook, Assistant Professor of Cancer Biology, explained: “These results highlight the link between the microbiome and breast health
.
” The researchers also conducted a double-blind placebo-controlled clinical trial on breast cancer patients.
Receive a placebo or fish oil supplement for about 2 to 4 weeks before lumpectomy or mastectomy
.
Fish oil supplements significantly changed the breast microbiome in non-cancerous and malignant breast tissues
.
The researchers also found that the proportional abundance of Bacteroides and Rumenococcus microorganisms in breast tumors of patients taking supplements is reduced, but its significance is unclear
.
"This study provides additional evidence that diet plays a key role in shaping the gut and breast microbiota," Dr.
Cook added
.
Looking ahead, researchers are further investigating whether probiotic supplements affect the microbial communities in breast and breast tumors
.
The researchers concluded: "This study shows that there is a link between the intestine and the breast that mediates the effects of diet on cancer
.
The results of the study highlight that dietary interventions may help reduce breast cancer risk
.
" Reference: https: //cancerres.
aacrjournals.
org/content/early/2021/06/01/0008-5472.
CAN-20-2983 Note: This article aims to introduce the progress of medical research and cannot be used as a reference for treatment options
.
If you need health guidance, please go to a regular hospital
.
Please indicate the source for reprinting.
Author: Yun Introduction: Many studies have proved the link between the gut microbiome and disease, but whether the gut and breast microbiome mediates the effect of diet on breast cancer influences? The scientist gave the answer! Breast cancer is one of the most common malignant tumors in women worldwide, and it is showing a rapid growth trend
.
Its incidence rate ranks first among female malignant tumors all year round, so it is often called the "pink killer"! Even more frightening is that according to the latest global cancer burden data released by the International Agency for Research on Cancer (IARC) of the World Health Organization in 2020, the number of new cases of breast cancer worldwide is expected to reach 2.
26 million in 2020, surpassing the 2.
2 million cases of lung cancer.
Replace lung cancer and become the world's largest cancer
.
Existing reports have shown that intestinal microbes can promote the occurrence of breast cancer by changing the level of systemic estrogen
.
This is generally considered to be a possible mechanism of breast cancer caused by a high-fat, low-fiber diet and antibiotic exposure
.
Later, researchers discovered a unique microbiome in breast milk and breast tissue
.
But so far, there have been few studies on the differences in the microbiota of breast tissue between breast cancer patients and healthy people.
Therefore, researchers have focused their attention on the study of intestinal microbes
.
Recently, researchers demonstrated that dietary patterns regulate the mammary gland microbiota
.
An important and unresolved question is whether the microbiome of the gut and breast mediates the effect of diet on breast cancer? To solve this problem, the researchers performed fecal transplants between mice on a controlled diet and a high-fat diet (HFD), and recorded the development of breast tumors
.
The research was published in the journal Cancer Research, entitled "Diet alters entero-mammary signaling to regulate the breast microbiome and tumorigenesis"
.
Researchers found that obesity and poor diet often complement each other, and together change metabolic signals, thereby affecting the risk of breast cancer
.
Many studies have proven the link between the gut microbiome and breast cancer.
For example, in January 2021, researchers found that when enterotoxigenic Bacteroides fragilis (ETBF) was introduced into the intestines or mammary ducts of mice , It can always induce the growth and metastasis of tumor cells
.
On June 13, 2019, a new study from the University of Virginia Cancer Center showed that an unhealthy, inflamed intestine can make breast cancer more aggressive and spread to other parts of the body more quickly
.
In this study, researchers used a multi-pronged approach to study animal models and breast cancer patients to understand the relationship between the microbiome, diet, and cancer risk
.
Now, new research by scientists at Wake Forest School of Medicine shows that diets that include fish oil supplements can not only change the breast microbiome, but also breast cancer
.
Mice susceptible to breast cancer were first fed a high-fat or low-fat diet
.
The researchers observed that mice on a high-fat diet had more tumors and tumors grew faster and larger in shape than mice on a low-fat diet
.
The researchers then performed a stool transplant to study the microbiome
.
Mice on a low-fat diet received a high-fat diet microbiome transplantation, and mice on a high-fat diet received a low-fat diet microbiome transplant
.
To their surprise, the researchers observed that mice that ate a low-fat diet and received a high-fat diet microbiome had roughly the same number of breast tumors as mice that ate a high-fat diet
.
Dr.
Katherine L.
Cook, Assistant Professor of Cancer Biology, explained: “These results highlight the link between the microbiome and breast health
.
” The researchers also conducted a double-blind placebo-controlled clinical trial on breast cancer patients.
Receive a placebo or fish oil supplement for about 2 to 4 weeks before lumpectomy or mastectomy
.
Fish oil supplements significantly changed the breast microbiome in non-cancerous and malignant breast tissues
.
The researchers also found that the proportional abundance of Bacteroides and Rumenococcus microorganisms in breast tumors of patients taking supplements is reduced, but its significance is unclear
.
"This study provides additional evidence that diet plays a key role in shaping the gut and breast microbiota," Dr.
Cook added
.
Looking ahead, researchers are further investigating whether probiotic supplements affect the microbial communities in breast and breast tumors
.
The researchers concluded: "This study shows that there is a link between the intestine and the breast that mediates the effects of diet on cancer
.
The results of the study highlight that dietary interventions may help reduce breast cancer risk
.
" Reference: https: //cancerres.
aacrjournals.
org/content/early/2021/06/01/0008-5472.
CAN-20-2983 Note: This article aims to introduce the progress of medical research and cannot be used as a reference for treatment options
.
If you need health guidance, please go to a regular hospital
.
