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| New progress in research on the effects of organic pollutants on the blood-brain barrier |
The blood-brain barrier is a barrier formed by a single layer of brain capillary endothelial cells and tight junctions between cells that exists between plasma and brain cells.
It has important biological significance for maintaining the normal physiological state of the central nervous system
.
Researchers believe that many persistent organic pollutants are highly fat-soluble, so they speculate that they can cause damage to the central nervous system through the blood-brain barrier, but there is no direct evidence to support this conjecture
Researchers from the Environmental Toxicology Discipline Group of the Institute of Hydrobiology, Chinese Academy of Sciences used human brain microvascular endothelial cells as the ex vivo blood-brain barrier model, and the transgenic zebrafish provided by the National Zebrafish Resource Center as the living blood-brain barrier model.
Bromophthalate (TBPH) was the object, and its ability to penetrate the blood-brain barrier and its effect on the structure and function of the blood-brain barrier were studied, and the resulting neurotoxic effects were evaluated
.
Related research was recently published in the "Journal of Hazardous Materials"
The results of in vitro studies showed that TBPH reached equilibrium in the matrix on both sides of Tanswell's chamber at about 6 hours, and its apparent permeability coefficient was much lower than the reference sodium fluorescein, indicating that TBPH has a low ability to penetrate the blood-brain barrier; but TBPH It can increase the permeability of the blood-brain barrier without affecting cell viability
.
Further in vivo studies have found that TBPH can increase the permeability of the zebrafish blood-brain barrier.
This may be because TBPH can interact with tight junction proteins, thereby affecting its structural integrity
.
Early exposure to TBPH has no significant effect on the development, neurotransmitter and running behavior of zebrafish juveniles, but it can significantly inhibit the phototaxis of juveniles
As a new brominated flame retardant (NBFRs), the content of TBPH in China's environment and biological media has increased rapidly, and has even surpassed traditional BFRs to become one of the most important NBFRs pollutants
.
The above research results help to further understand the neurotoxicity and mechanism of TBPH, and also point out that TBPH may cause potential harm to aquatic organisms
This research was completed by postgraduate student Liu Sitian and others.
Associate researcher Yang Lihua is the corresponding author
.
The research was funded by the National Natural Science Foundation of China (42177268, 21737005), the Postdoctoral Fund (2019M652736) and the State Key Laboratory of Freshwater Ecology and Biotechnology (2019FBZ03), as well as the support of the National Zebrafish Resource Center
Related paper information: https://doi.
https://doi.
org/10.
1016/j.
jhazmat.
2021.
127386
