New peptide can treat heart attack

Stroke, heart attack and traumatic brain injury may not seem to be closely related to each other, but they often have some common pathological manifestations, and the final result is the same, that is, cell death, and patients often cause hypoxia and damage to the body; in these diseases, the tissues affected by the lack of blood supply will open the molecular signal pathway to stop Recently, researchers from bangulion University have been searching for human derivatives (human is a neuroprotective factor) and found that using a natural peptide encoded by mitochondrial genome in cells can successfully block the above process Professor Abraham parola, the researcher, said that the current research provides new hope for the development of new drug therapy to treat necrosis related diseases, such as traumatic brain injury, stroke and myocardial infarction, and there is no effective therapy to treat these diseases Humanin derivatives can play a role by neutralizing the decrease of ATP level caused by necrosis In this paper, the researchers tested the efficiency of human analog AGA (C8R) - hng17 and aga-hng by using the newly discovered natural polypeptides to treat the neurons exposed to necrosis factor The experimental results showed that it was effective In previous studies, researchers clarified the mechanism of antiangiogenic drugs and the dynamic changes of cell membrane Antiangiogenic drugs can promote the death of malignant tumor cells by inhibiting the supply of nutrients and oxygen to fast-growing tissues, while the results of this study revealed that cardiolipin also participated in the above process At present, researchers are using hng17 analogues to conduct in vivo experiments on mice with traumatic brain injury, so as to successfully reduce the accumulation of intracranial fluid and the severity fraction of neurons in mice With the deepening of the research, they found that the drug delivery system using hng17 may be more effective in treating patients' diseases In the later stage, researchers will further explore the mechanism of ischemic activity in liver cirrhosis patients and how to induce ischemic activity through acetaminophen At the same time, researchers hope that in Humanin and other anti-necrosis agents To find a synergistic effect, such as protease inhibitor, to increase its clinical effect.