New mushroom toxin is the cause of unexplained sudden death in Yunnan

On January 27, Liu Jikai, research group of Kunming Institute of Botany, Chinese Academy of Sciences, and Zeng Guang, research group of China Center for Disease Control and prevention, published a paper online at angew Chem Int ed., and reported the new mushroom (trogia) from Yunnan Two new non protein amino acid toxic components were found in venenata), and it was confirmed that the accidental ingestion of the mushroom was the cause of unexplained sudden death in Yunnan Province for more than 30 years For more than 30 years, dozens of unexplained sudden deaths occur every year in mountain villages with an altitude of 1800-2600 meters in the north of Yunnan Province, most of which occur in the rainy season from July to September This situation has attracted great attention of the state and local governments, and many experts have been organized to study and try to find out the reasons However, due to the high complexity of the situation, there is no conclusion After a long time of careful and in-depth study, the project team found that trogia venenata was a risk lethal factor Since 2008, two new nonprotein amino acids have been found and purified from animal experiments The researchers confirmed its chemical structure and absolute configuration through total synthesis, and detected the new amino acids contained in mushrooms from the blood of dead people by LC-MS / MS method For the first time, the direct evidence confirmed that the dead people had eaten the mushroom before they died It was found that the lethal mechanism of the compound was very complex, and it played a role in the heart and metabolism Intraperitoneal administration will lead to the rise of creatine kinase in mice Further animal experiments showed that the extract of the fungus caused a sharp decrease in blood sugar in a short period of time According to the results of the study, the researchers intervened, printed a large number of brochures, distributed them in areas of danger and sudden death, and warned people not to eat the fungus The intervention had a significant effect and no similar sudden death was reported in 2010 and 2011 The research project was supported by the 973 Program of the Ministry of science and technology, the key program of the National Fund Committee, the program of the Ministry of health and the knowledge innovation program of the Chinese Academy of Sciences.