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Scientists at the Center for Molecular Medicine research at the Austrian Academy of Sciences have shown that targeting the chromatin protein SMNDC1 will stimulate alpha cells to produce insulin
The findings were published in the journal Cell Reports
"The expression of insulin is mainly limited to the pancreas β cells, the body or functional failure
Previous research has shown that α cells can be converted into β cells through gene overexpression, which involves a combination
Tamara Castiles, a PhD student in Dr.
Castles was able to demonstrate that reducing the expression of the chromatin protein SMNDC1 leads to the opening
This effect was observed not only in mouse cell lines, but also in the main human islets of Langerhans
Kubicek explains: "Splicing is a step in the mRNA processing process in which non-coding intron sequences are cut off
These findings shed light on the rationale
"After SMNDC1 is knocked down, the amount of insulin induced in α cells is significantly lower than the amount of insulin induced in β cells
