New mechanisms for tumors to evade immune attacks have been discovered

The team of Professor Zhang Yi and Professor Zhao Jie of the First Affiliated Hospital of Zhengzhou University has made new progress in the study of the immune and metabolic mechanisms associated with pulmonary adenocarcinoma: the team found that the combined targeted metabolic therapy of tumor immunotherapy may be an effective strategy for treating pulmonary adenocarcinoma. The research paper was published online in Molecular Cancer, an international authoritative journal in the field of oncology.metabolic reprogramming is one of the important characteristics of malignant tumor cells, which can help them adapt to tumor micro-environment and fight various anti-tumor treatment methods. Changes in glycogen metabolism are an important part of cancer cells' efforts to adapt to tumor microencourses. Professor Zhang Yi and Professor Zhao Jie's team took the tumor immune microenvironment as the starting point, and based on the results of gene sequencing, they found that after the tumor cell metabolic molecule glycogen branch enzyme 1 was knocked down, it was possible to induce the production of type I interferon by interferon activation protein signaling path, thus enhancing the ability of chemokine to recruit T lymphocytes. This process is accompanied by an increase in the expression of the pathogenic death receptor 1 receptor on the surface of tumor cells. The study suggests that glycogen branchase 1, a negative regulatory molecule that activates protein pathlines of interferon, may be a potential target for lung adenocarcinoma treatment, especially with immuno-checkpoint inhibitors in the treatment of lung adenocarcinoma., the research team is further developing the feasibility hypothesis based on preliminary research to look for the possibility of combining anti-metabolic therapy with immuno-checkpoint inhibitor therapy for anti-tumor therapy. With the in-depth study of the micro-environment of immunosuppression of metabolic regulated tumors, the theory of anti-tumor function based on metabolic pathway regulation of immune cell function may become a reality in future cell therapy and be applied to tumor therapy. (Health Journal)