New mechanism for low back pain to occur is revealed
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Last Update: 2020-05-31
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Source: Internet
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Author: User
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The first author of the paper, DrShuangfei, introduced that there is a structure called "cartilage end plate" in the intervertebral disc of the mammalian spineThe final plate is located between the semi-fluid, glued myelin core and the bone vertebrae and is subjected to a large shear stressIt was found that in the process of spinal degeneration, cartilage final plate calcification occurred, and the neuroguided sensory nerve gradually grew into the final plate tissueInhibiting bone-breaking cell activity, or specifically knocking out the Netrin-1 factor, can significantly relieve the long-term intake of sensory nerves in the final plate and relieve spinal painThe study further found that specific ally knocking out EP4 receptors on the sensory nerve also significantly alleviated pain allergies in micethesis systematically explains the mechanism of sensory nerve growth into the final plate and activation and pain allergy in mice, and reveals a new theory of the occurrence of low back pain, which provides a new way of understanding the diagnosis and treatment of low back pain.
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