New link between long-term arsenic consumption and type 2 diabetes

A health science research conducted by the University of Arizona has determined the biological mechanism between long-term exposure to arsenic and diseases such as cancer and type 2 diabetes

According to data from the Centers for Disease Control and Prevention, there are more than 34 million diabetic patients in the United States, of which approximately 90-95% suffer from type 2 diabetes

Since arsenic is a natural metal found in the soil, it may be one of the most serious pollutants in drinking water in the world, especially when ingested at unsafe levels

The new research led by Dr.

This study examined the effect of arsenic exposure on the activation of nuclear factor red blood cell 2 related factor 2 (NRF2)

Long-term oxidative stress, such as oxidative stress caused by smoking, radiation, high-sugar, high-fat, and high-alcohol diets or environmental toxins, can lead to the development of a series of chronic diseases, including cancer, diabetes, and neurodegenerative diseases

NRF2 is a regulatory factor of the body's anti-oxidative stress

Dr.

The results of the study indicate that the prolonged activation time of NRF2 in response to arsenic increases the production of glucose in the liver and the release of glucose to the blood, which may be a key driving factor for changes in systemic blood sugar

The toxicity of arsenic has been known to humans as early as thousands of years ago, but it was not until modern times that people began to understand the health problems caused by ingesting arsenic through meals

A 2012 study showed that 45.

"It is hoped that this research will become the basis for future research on toxin-driven diabetes in the University of Arizona Health Science and elsewhere," said Dr.

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Molecular Metabolism

DOI

10.