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Known as the "king of cancer" melanoma, its treatment is still a great challenge, from molecular drugs to targeted therapies to immunotherapy, scientists have been updating their treatment plans
.
But even if the immunotherapy is effective, it may only be effective for 50% of patients.
Given that some tumors that are resistant to immune checkpoint inhibitors can also be treated by NK cell therapy, experts in the field of cell therapy turn to Hope to put it on NK cell therapy
.
Now, researchers from Washington University School of Medicine in St.
Louis are trying to use NK cell therapy to treat melanoma
.
Studies have found that cytokine-induced memory-like differentiation enhances the response of NK cells to melanoma, which can be used as one of the treatment strategies for melanoma.
The relevant research results were published under the title "Memory-like Differentiation Enhances NK Cell Responses to Melanoma" In the journal "Clinical Cancer Research"
.
Researchers collected blood from patients with stage IIIC/IV melanoma, and detected immune cells in the blood using a mass spectrometer, and found that NK cells showed decreased expression of activated receptors and decreased cytotoxicity
.
This also means that the NK cells of melanoma patients cannot effectively attack cancer cells
.
Therefore, in order to effectively control melanoma cancer cells, it is necessary to strengthen the killing power of NK cells to cancer cells.
This also shows that methods to improve the anti-melanoma activity of NK cells are necessary for effective autoreaction
.
So how to improve the activity of NK cells against melanoma? The researchers carried out further research
.
Previous studies have shown that human NK cells that are temporarily activated by IL12, IL15, and IL18 receptors differentiate into memory-like (ML) NK cells, and these cells display enhanced functions, including anti-tumor responses
.
Therefore, in this new study, the researchers tested the therapeutic effect of melanoma patients after NK cells were differentiated into memory-like NK cells
.
Experiments have shown that, compared with ordinary NK cells, the "evolved" NK cells show sustained and enhanced cytotoxicity when facing human melanoma cells DM6 and M14, which indicates that memory-like NK cells control melanoma targets in vitro The ability to point is significantly enhanced
.
(Illustration: Memory-like NK cells show a stronger ability to control melanoma) Since the NK cells of healthy blood can complete the "glorious transformation", can the NK cells of melanoma patients also complete the same "evolution", thus How about rewriting the treatment effect? In order to find the answer, the researchers extracted peripheral blood mononuclear cells from patients with advanced melanoma and stimulated them to differentiate NK cells into memory-like NK cells, and validated the treatment with melanoma cancer cells derived from the patients themselves.
Effect
.
The results show that compared with normal NK cells, memory-like NK cells have significantly increased specific killing of autologous melanoma cells, indicating that memory-like NK cells differentiated from patients with advanced melanoma have a strong ability to control melanoma
.
Finally, the researchers established a humanized tumor mouse model to evaluate the ability of human memory-like NK cells to control melanoma targets
.
First, 1×105 melanoma cancer cells were injected into mice, and 5×106 control NK cells or memory-like NK cells were injected one day later, and then the burden of melanoma was monitored regularly
.
It was found that, in contrast, mice injected with memory-like NK cells had a stronger ability to control melanoma cells, and the tumor burden in the body was controlled during the entire test period
.
In short, combined with the test results, blood NK cells from patients with advanced melanoma can differentiate into memory-like NK cells under the action of cytokines.
These cells have a stronger ability to control melanoma cells and can be used as a treatment for advanced melanoma.
New immunotherapy
.
It is hoped that this new immunotherapy can be tested in early clinical trials as soon as possible, so that more patients with advanced melanoma can be cured
.
In order to facilitate you to continue to receive our articles, you are welcome to set us as a "star" so that you can see our news in the future
.
End reference materials: [1]https://clincancerres.
aacrjournals.
org/content/27/17/4859#sec-14
.
But even if the immunotherapy is effective, it may only be effective for 50% of patients.
Given that some tumors that are resistant to immune checkpoint inhibitors can also be treated by NK cell therapy, experts in the field of cell therapy turn to Hope to put it on NK cell therapy
.
Now, researchers from Washington University School of Medicine in St.
Louis are trying to use NK cell therapy to treat melanoma
.
Studies have found that cytokine-induced memory-like differentiation enhances the response of NK cells to melanoma, which can be used as one of the treatment strategies for melanoma.
The relevant research results were published under the title "Memory-like Differentiation Enhances NK Cell Responses to Melanoma" In the journal "Clinical Cancer Research"
.
Researchers collected blood from patients with stage IIIC/IV melanoma, and detected immune cells in the blood using a mass spectrometer, and found that NK cells showed decreased expression of activated receptors and decreased cytotoxicity
.
This also means that the NK cells of melanoma patients cannot effectively attack cancer cells
.
Therefore, in order to effectively control melanoma cancer cells, it is necessary to strengthen the killing power of NK cells to cancer cells.
This also shows that methods to improve the anti-melanoma activity of NK cells are necessary for effective autoreaction
.
So how to improve the activity of NK cells against melanoma? The researchers carried out further research
.
Previous studies have shown that human NK cells that are temporarily activated by IL12, IL15, and IL18 receptors differentiate into memory-like (ML) NK cells, and these cells display enhanced functions, including anti-tumor responses
.
Therefore, in this new study, the researchers tested the therapeutic effect of melanoma patients after NK cells were differentiated into memory-like NK cells
.
Experiments have shown that, compared with ordinary NK cells, the "evolved" NK cells show sustained and enhanced cytotoxicity when facing human melanoma cells DM6 and M14, which indicates that memory-like NK cells control melanoma targets in vitro The ability to point is significantly enhanced
.
(Illustration: Memory-like NK cells show a stronger ability to control melanoma) Since the NK cells of healthy blood can complete the "glorious transformation", can the NK cells of melanoma patients also complete the same "evolution", thus How about rewriting the treatment effect? In order to find the answer, the researchers extracted peripheral blood mononuclear cells from patients with advanced melanoma and stimulated them to differentiate NK cells into memory-like NK cells, and validated the treatment with melanoma cancer cells derived from the patients themselves.
Effect
.
The results show that compared with normal NK cells, memory-like NK cells have significantly increased specific killing of autologous melanoma cells, indicating that memory-like NK cells differentiated from patients with advanced melanoma have a strong ability to control melanoma
.
Finally, the researchers established a humanized tumor mouse model to evaluate the ability of human memory-like NK cells to control melanoma targets
.
First, 1×105 melanoma cancer cells were injected into mice, and 5×106 control NK cells or memory-like NK cells were injected one day later, and then the burden of melanoma was monitored regularly
.
It was found that, in contrast, mice injected with memory-like NK cells had a stronger ability to control melanoma cells, and the tumor burden in the body was controlled during the entire test period
.
In short, combined with the test results, blood NK cells from patients with advanced melanoma can differentiate into memory-like NK cells under the action of cytokines.
These cells have a stronger ability to control melanoma cells and can be used as a treatment for advanced melanoma.
New immunotherapy
.
It is hoped that this new immunotherapy can be tested in early clinical trials as soon as possible, so that more patients with advanced melanoma can be cured
.
In order to facilitate you to continue to receive our articles, you are welcome to set us as a "star" so that you can see our news in the future
.
End reference materials: [1]https://clincancerres.
aacrjournals.
org/content/27/17/4859#sec-14
