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New immune checkpoint for pancreatic cancer discovered

 Last Update: 2022-01-01
 Source: Internet
 Author: User

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In recent years, immune checkpoint blocking therapy has shown success in the treatment of many types of tumors, but it has been helpless against pancreatic cancer, which is known as the "king of cancer

For a long time, immune checkpoint blocking therapy based on programmed death receptors and their ligands has not worked against pancreatic cancer

Through a variety of sequencing and screening, the research team found that osteopontin and its ligands are another immune checkpoint besides the programmed death receptor and its ligands, which promote the development of pancreatic cancer by compensating for the function of the programmed death receptor.

Studies have found that the inhibitor WDR5-47 can effectively inhibit the expression of osteopontin in pancreatic tumor cells and myeloid-derived suppressor cells, and has great potential to be developed as an immunotherapy monotherapy for the treatment of pancreatic cancer

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