New discovery! Parkinson's disease or not a type, divided into body-first and brain-first!

September 29, 2020 // -- A recent study published in the international journal Brain entitled "Brain-first versus bo dy-first Parkinson's disease: a multimodal caseimaging-control study", from Aohus University Scientists at other agencies have found that Parkinson's disease may not be a disease, but two, and that it starts in the brain or intestines, which explains why people with Parkinson's disease describe different symptoms, while the researchers also point out that individualized medication may be a potential way to treat people with Parkinson's disease.
researcher Per Borghammer points out that with the help of advanced scanning techniques, we have now demonstrated that Parkinson's disease can be divided into two variants, starting in different parts of the body and, for some patients, starting in the intestines and passing through them. Neural connections spread to the brain, and for others, the disease begins to occur from the brain and spread to the intestines and other organs such as the heart; the findings may be important for future scientists to develop treatments for Parkinson's disease, depending on the disease patterns in each patient's body.
Parkinson's disease is characterized by a slow deterioration of the brain caused by the accumulation of α-synth nucleoproteins, a nerve cell that damages nerve cells, which can lead to slow, stiff movements associated with the disease in many people.
Photo Source: In the Wikipedia study, researchers used advanced PET and MRI imaging techniques to analyze patients with Parkinson's disease, and patients with undiagnosed high-risk diseases were included in the study, which increased the risk of Parkinson's disease in individuals diagnosed with REM behavioral syndrome.
Studies have shown that some patients have damaged the dopamine system in their brains before damage to their intestines and heart, while in others scans have shown damage to the body's intestines and heart's nervous system before damage to their brain dopamine systems.
researchers say the findings are important in changing scientists' understanding of Parkinson's disease, which many now see as a relatively single disease and is defined by typical movement disorders, but at the same time, researchers have been wondering why there are so many differences between the symptoms of the disease in different patients.
researchers defined two types of Parkinson's disease as body first and brain first, and in the case of body first, they were interested in studying the composition of the gut microbiome known as the microbiome.
The researchers have long found that the gut bacteriobiomes of people with Parkinson's disease are different from those of healthy people, and now they have identified two types of Parkinson's disease so that they can study the risk factors and possible genetic factors of both types of Parkinson's disease, and the next step is to study whether using fecal transplants or other methods that affect the microbiome can effectively treat the body. Priority Parkinson's disease; Finding brain-first Parkinson's disease is a bigger challenge for scientists, and patients with this mutated disease may be relatively asymptomatic until they develop symptoms of movement disorders, by which time they have lost more than half of their dopamine system, so it may be possible to intervene and slow the progression of the disease as early as possible. the
researchers' study, which is longitudinal, will bring participants together again in three and six years so that all tests and scans can be repeated, which they say could make it the most comprehensive study ever conducted to help researchers shed light on the specific pathogenesis of Parkinson's disease and provide new clues to the development of new treatments later in life.
Previous studies have shown that there may not be more than one type of Parkinson's disease, but this may not have been clearly demonstrated until researchers carried out this study, and now researchers' research offers new hope for deeper, more targeted treatments for Parkinson's disease later in life.
According to the Danish Parkinson's Disease Association, there are currently 8,000 people with Parkinson's disease in Denmark, and about 8 million people worldwide are at increased risk of Parkinson's disease as the population ages, and that number is expected to rise to 15 million by 2050.
() References: 1. Parkinson's disease is not one, but two diseasesby Aarhus University (2) Jacob Horsager, Katrine B Andersen, Karoline Knudsen, et al. Brain-first versus body-first Parkinson's disease: a multimodal imaging case-control study, Brain (2020). DOI: 10.1093/brain/awaa238.