New discoveries have been made to inhibit breast cancer immersion mechanisms

most breast tumors usually begin in the endocrine cells of the breast breast tube, which in turn are surrounded by myothic cells. Previously, scientists believed that the cell layer of myothystic cells was a static barrier against cancer immersion.
Recently, experiments in laboratory-cultured mouse tissue at Johns Hopkins University in the United States showed that the cell layer around the breast breast tube was able to protrude and capture escaped cancer cells to prevent them from spreading in the body. This suggests that the cellular layer of myothic cells is an active defense mechanism that inhibits breast cancer metastasis. The results of the experiment were published online July 30
July.
it is understood that the myothyric cortical layer is clinically used to diagnose the differentiation between restrictive breast cancer and immersive breast cancer in humans. If breast cancer cells break through the upper cortical layer of the muscle, the result is so-called immersive cancer, which has a higher recurrence rate and requires more aggressive treatment.
if cancer metastasis is seen as a long-distance race, breaking through the cell layer is equivalent to rushing out of the starting line," he said. "Understanding how cancer cells are restricted can help us develop ways to predict individual cancer metastasis risk," said Andrew Ewald, a professor of cell biology at Johns Hopkins University School of Medicine and a member of the Johns Hopkins Sidney Kimmel Comprehensive Cancer Center. In
study, Ewald and his team modified cells taken from the inner breast of mice to produce the protein Twist1, which works by altering gene expression and is associated with cancer metastasis in multiple tumor types.
, the researchers found that when immersive Twist1 cells broke through the upper cortical layer, the myothic cells were able to catch the escaped cells. In 92% of the 114 observations, it was pulled back into the breast catheter.
The results establish a new concept of endotebial cells as a dynamic barrier against cell escape, rather than acting as static blockers, as previously speculated," said Katrina Sirka, a doctoral student at Ewald Labs. To
confirm their findings as an active behavior, not just because of the cell's natural "stickyness," Ewald and his team changed two key characteristics of myothic cells: their shrinkage and their ratio to the number of soaked cells.
, the researchers genetically modified the mouse muscle endothoste cells to remove their smooth myocardial protein, a protein that causes cells to contract. In this case, the number of escape-immersed cells breaking through the upper cortical layer increased threefold compared to the normal myothystic cells as a control.
also found that reducing the ratio of myothystic cells to immersive cells also increased the number of escaped cancer cells. The escape rate is reduced to 1/4 by adding two myothic cells to each impregnable cell compared to the diffusion of immersive cells without a defensive barrier.
"This is important because it shows that the physical integrity of epithal cells and gene expression within myothic cells are important for predicting the behavior of breast tumors in humans," said Eliah Shamir, a surgical pathology researcher at the University of California, San Francisco. Cancer cells may escape where the upper cortical layer thins or falls off. For
, Ewald and his team plan to study the cellular mechanisms that cause dynamic reactions in the endosthal cortical layer, as well as the causes of immersion caused by their failure. (Source: Zhang Siwei, China Science Daily)