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| New coronavirus infection and genetic factors of the disease are determined for the first time |
| Thirteen new relevant genomic regions identified |
Science and Technology Daily, Beijing, July 8th (Reporter Zhang Mengran) A large-scale international collaborative research analysis has determined for the first time the genetic factors of human neocoronavirus infection and neocorona pneumonia disease severity, and identified factors related to susceptibility and disease severity.
13 new genomic regions
.
This genetic analysis, published on the 8th in the British journal Nature, covers 46 studies of nearly 50,000 patients with new coronary pneumonia in 19 countries.
The genetic makeup of an individual affects the susceptibility and response to viral infections.
Although environmental, clinical, and social factors play a role in the severity of COVID-19 and COVID-19 disease, host genetics is also very important
.
Studies have shown that factors such as men, heavier weight, and older age will increase the severity of the disease in patients with new coronary pneumonia, but these risk factors alone cannot explain the various changes in the severity of the disease
.
Host genetics has now been shown to play an important role in the susceptibility and severity of infectious diseases (including respiratory viruses)
Based on these studies, a meta-analysis of the genome-wide associations of patients with new coronary pneumonia has found new loci related to the severity of new coronavirus infection or new coronary pneumonia
.
The research team including scientists from the Finnish Institute of Molecular Medicine found that some of the loci identified this time overlap with the loci previously associated with autoimmune diseases, inflammatory diseases, or lung diseases
The researchers concluded that this international cooperation has identified new host genetic factors related to the new coronary pneumonia at an unprecedented speed, and will continue to collect data to bring the scale and diversity of the lineage covered by the analysis to a higher level
Focus on the new crown pneumonia epidemic
