New bioactive polypeptides have significant effect on wound healing

The researchers combined bioactive peptides to successfully stimulate wound healing In vitro and in vivo studies have confirmed that the combination of the two peptides can stimulate vascular growth and promote tissue regeneration In the future, these peptides may further develop into new therapeutic methods for chronic and acute trauma Relevant research papers were published in PLoS One The team tested a newly manufactured peptide, UN3, in the hope that it could stimulate the healing of damaged blood vessels in a pre bed model, which is common in patients with peripheral vascular disease or diabetes The polypeptides increased the development of vascular wall by 50%, the growth of vascular increased by 250%, and the migration of endothelial cells increased by 300% Dr Tatiana Demidova rice, a graduate of the cell, molecular biology and developmental biology graduate training program of secler school and the first author of the article, said: "in the double-blind in vivo experiment, we combined the comb1 made in the early research with the wound healing polypeptide UN3 We found that the combination of polypeptides was better than the control group in wound healing In the control group, becaplermin, the only drug containing growth factor approved by FDA, was included In December 2010, Herman and Demidova rice identified several peptides produced by Clostridium histolyticus after administration of biosynthetic extracellular matrix collagenase The researchers then studied these key peptides in depth and produced a peptide named comb1 Comb1 has some functions of these key peptides, including increasing vascular growth in vitro by 200% to stimulate angiogenesis Currently, it is found that the second wound healing peptide UN3 is modified by two naturally occurring (known) peptides These two known peptides are usually present in human platelet rich plasma Dr IRA Herman, Professor of molecular physiology and pharmacology at Tufts University School of medicine, said: "it is of great significance for our research results to go to clinical application to confirm the synergistic effect of these peptides to improve human wound healing." Professor Herman is the leader of the cell, molecular biology and developmental biology postgraduate training program at secler school Herman said: "the function of wound healing polypeptides should be further studied to confirm whether these polypeptides can be used for the reconstruction of living tissues of burn patients, patients with diabetic plantar disease or venous stasis ulcer need to further prove The next research plan is to carry out clinical trials of these wound healing polypeptides." Tufts University has applied for patents on wound healing polypeptides.