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New approach to anti-HIV antibody therapy shows promise in phase I clinical trial

 Last Update: 2022-05-28
 Source: Internet
 Author: User

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AAV vectors can be safely used in the body to deliver DNA into cells, and two AAV-based gene therapies are currently FDA-approved

The Phase 1 clinical trial enrolled eight HIV-infected adults who had been on stable antiretroviral therapy for at least 3 months

"This work represents the first successful AAV-based production of monoclonal antibodies of any type by anyone," said co-author Alejandro B.

The findings have broad clinical implications for the possible prevention or treatment of HIV and other infections, Balazs noted

The technique was originally developed by Balazs as a postdoc in the laboratory of Nobel laureate Dr.

Additional study authors include Joseph P.

This work was supported by internal funding from the National Institute of Allergy and Infectious Diseases through the NIH Internal Research Program

Journal Reference :

Joseph P.

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