New advances in cancer hunger therapy! Shanghai Cancer Therapy is published in the journal Nature.

Nature Nanotechnology, an internationally renowned academic journal, recently published online the research paper "Magnesium Jicide nanoparticles as a deoxygenation agent for the science and technology" (Nanotechnology, " in collaboration with the research team of Professor Stepping Bo of the School of Chemistry and Molecular Engineering of the Shanghai Green Chemical and Chemical Process Key Laboratory, in collaboration with the Shi Jianlin Research Group of the Shanghai Institute of Siliats Of the Chinese Academy of Sciences. 2016, DOI: 10.1038/nnano.2016.280;starting from the synthesis of new Mg2Si nanoparticles by self-spreading combustion method, the
reveals a new phenomenon in which the tumor microenvironment can specifically activate the oxygen-consuming function of Mg2Si nanoparticles and the decomposition products to clog tumor blood vessels, and pioneers the new ideas for inorganic oxygen consumption for tumor hunger therapy, and injects new vitality into the traditional tumor hunger therapy.
tumors grow in the human body, need to form their own vascular networks to provide the necessary oxygen molecules and nutrients for tumor tissue growth, so "blood vessels" is the tumor's "life gate";
unfortunately, due to the harsh requirements of "tumor hunger therapy" for inorganic materials (such as meeting the specificity of tumor tissue, oxygen consumption, blocking vascular persistence, injectability, good biocompatibility, etc.), inorganic materials are not yet available for tumor hunger therapy.
recently, the cooperation team of Professor Pawenbo of the School of Chemistry and Molecular Engineering of East China Normal University and Shi Jianlin Researcher of the Shanghai Silicate Research Institute of the Chinese Academy of Sciences successfully prepared a single-dispersed, mg2Si-nano-oxygen-consuming agent with a single dispersion, about 100 nm diameter, and a stable solution after surface modification of polyethylene pyrethroid (PVP) to give it a good injection.tumor hunger therapy schematic
experimental results show that the new oxygen-consuming agent is specifically activated in the weak acidic microenvironment of tumor tissue, using the intermediate product silane (SiH4) to quickly and efficiently consume dissolved oxygen and hemoglobin binding oxygen in tumor tissue and blood vessels, resulting in extreme hypoxia in the tumor lesions area; The molecular and nutrient strains through the supply of tumor vascular system, but also cut off the tumor invasion, metastasis vascular pathway, resulting in cancer cells to occur obvious fibrosis, apoptosis and necrosis, to achieve the "starvation tumor" treatment effect; Not only has good biocompatibility, its decomposition products (Mg2 plus and SiO2) are also non-toxic and harmless, and are finally safely metabolized out of the body, overcoming the medical inorganic materials difficult to degrade, live body retention easy to lead to biotoxic medical problems. This work provides a new method for the bulk preparation of new functional nanomaterials, and also provides a new way of thinking for "tumor hunger therapy".
the study was published online in the form of an article in Nature Nanotechnology and ranked second in the most popular papers. As soon as the work was published, it received wide attention from the international academic community, and the research results were featured and highlighted by several international authoritative academic journals/news media, such as Chem, the American Chemical Society Chemical Society, Chemical and Engineering News and the World Science and Technology Research News Network. The research work was supported by the National Natural Science Foundation of China and the Shanghai Science and Technology Commission's Outstanding Academic Leaders Program. (The content is from the official website of East China Normal University)
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