New achievements made by scientists in the field of organ transplantation!

"This article collates the recent achievements made by scientists in the field of organ transplantation research to learn with you! FILE Photo: A new technology has been developed that can significantly improve the success rate of organ transplantation in human sands: In a recent study published in the international journal, scientists from the Vanderbilt University Medical Center and others have shown that using cross-loops between human lungs and heterogeneous hosts can restore the function of damaged lung tissue in human donors that have been blocked by transplanting; M.Dsays the lungs are the least commonly used for transplanting solid organs because the donor lungs are considered adequate for transplants, and if we can raise this acceptance rate to or perhaps be effective in saving patients on the waiting list, more patients will receive lung transplantsIn earlier studies, researchers said that cross-looping techniques using animal models could not only support but also restore the lungs of animals for up to a day, and the current study has successfully extended to human lungs that cannot be transplanted because of severe damage: Heavyweight! Chinese scientists' successful conversion of the spleen into a liver-like organ could solve the dilemma facing liver organ transplantationIn a recent study published in the international journal, scientists from Nanjing University and other institutions have developed a new method or can induce mice's spleen to exhibit liver-like behavior in a new alternative to organ transplantsLiver disease is common in many people around the world Many patients who need a liver transplant often die before waiting for the transplanted organ to die, which is why medical scientists are desperate to find other ways to treat liver disease or whether other strategies can be used to replace the liver of patientsThe spleen is an organ of the body's abdomen that plays a key role in the production and removal of blood cells and is considered an important part of the body's immune system but its function is very limitedThis is why people can survive because of impaired spleen function or survive the removal of the spleenScientists have succeeded in making human organs "transparent" and are expected to help develop "artificial organs" for organ transplants: Scientists from institutions such as the German Center for Environmental Health Research have been successful in making complete human organs transparent for the first time in a recent study published in an international journalUsing microscope imaging techniques researchers can reveal the complex structure of transparent organs at the cellular level, although the resulting organ map can serve as a template for bioprinting technology Future researchers or hopefully develop the "artificial organs" that patients needThe lack of a lack of technology to image human organs at cell levels has been a huge challenge for scientists to solve the structural complexity of human organs, and the latest developmentin in tissue removal technology has allowed researchers to obtain for the first time cell images of fully transparent mouse organs, but these methods do not apply to human organsBecause human organs that have accumulated in soluble molecules, including collagen, in tissues over the years and even decades, become particularly rigid, the detergents traditionally used to make mouse organs transparent may not work, especially in adultsThe researchers say we must radically change the methods currently used to constantly look for new chemicals that make human organs transparent from scratch; after repeated experiments, researchers have discovered a cleaner called a "small hole" that can make "small holes" in complete, rigid human organs that allows extra solutions to penetrate into several centimeters of human organs and transform them into what is called a transparent structureGrowing hormones may significantly improve postoperative survival in liver transplant patients: Growth hormone is thought to play a key role in reducing inflammation and increasing survival rates after liver surgery, a study published in the international journal, scientists from the University of Queensland and others, used mice to study how body growth hormone helps the liver regenerateThe researchers said that if mice lacked receptors that transmit growth hormone signals to cells, mice that would not be able to survive carrying normal growth hormone receptors after surgically removing two-thirds of their livers would often survive after cutting two-thirds of their livers and would undergo a full liver regeneration processGrowth hormone induces the production of a protein called a protein, which inhibits the body's inflammatory response after surgeryBy injecting proteins into mice that are missing growth hormone receptors, researchers can effectively reduce inflammation and promote liver regeneration and survival in mice """""""In-depth analysis! The new --based technology promises to quickly and easily detect infection risk and rejection in kidney transplant patients! Scientists from the Massachusetts Institute of Technology and others have developed a new diagnostic technique based on the development of a new diagnostic technique to detect the risk of infection in patients after organ transplants while monitoring patients' rejection of transplanted organs, according to a study published in the international journal Infection and rejection during organ transplantation are the main causes of transplant failure, and they are linked together through immunosuppressive states in order to be able to diagnose and treat these conditions as early as possible and improve the long-term prognosis of patients A fast and inexpensive test has been developed to accurately detect polymatoma viruses () and cytomegaloviruses () from blood and urine samples in the patient's body, as well as elevated levels of urine (markers of rejection of transplants) in patients experiencing acute renal transplant rejection; Photo Source: Successfully Regulating immune rejection of the transplanted tissue of the recipient body using induced pluripotent stem cells: In a recent study published in the international journal, scientists from Hokkaido University developed a new method that can regulate the body's immune response to transplanted organs using induced pluripotent stem cells The researchers found that thymus epithelial cells derived from mouse-induced pluripotent stem cells regulate the body's immune response to skin grafts and extend the life of the graft The thymus is located behind the thoracic bone, which is an important organ cell that produces cells that can control the body's immune response, including organ rejection, and is directly related to immune self-tolerance, and it can also act as an important member of the body's immune system to treat the antigen produced by the body itself as a non-dangerous substance Pluripotent stem cells such as embryonic stem cells and induced pluripotent stem cells can differentiate into multiple types of cells which can usually be used as an alternative source of tissue transplantation in the body but when the transplanted donor's organs or tissues are rejected and eventually destroyed by the immune system of the recipient body, so the most important in regenerative medicine is the successful regulation of the host's immune response to the transplant "Super islet transplants help treat diabetes: Pancreatic cell transplants are often the last option in order to treat patients with severe diabetes, characterized by a lack of functional insulin-generating cells." The pancreas contains a class of cells called """"" which produce hormones that regulate blood sugar that can help relieve the symptoms of diabetes by transplanting normal lying cells The transplant process, however, is long and complex: a large number of transplanted cells can quickly die, leading to the failure of the transplant Researchers from the University of Geneva in Switzerland and others recently succeeded in creating a stronger "super islet" tissue by adding amniotic epithelial cells to these clusters Transplanting these islet tissues will allow more islet cells to survive, helping to produce insulin more quickly The results were published in the journal To improve the success rate of islet transplantation and the survival rate of transplanted cells, researchers in Geneva sought to create a new, stronger islet so that it could withstand the stress of transplantation more than natural islets So they came up with the idea of extracting the endothelial cells of the amniotic membrane from the wall of the placenta to the pancreatic cells "These cells are very similar to stem cells and have been used in other therapies such as corneal repair "In our study, we found that they promote the function of pancreatic cells in regulating blood sugar levels, " said the author, a professor and director of the Department of Surgery in the Department of Medicine Finding regenerative liver and bile-mixed progenitor cells is expected to replace liver transplantation: Researchers at King's College London have discovered a single-cell sequencing technique that can regenerate liver tissue cells to treat liver failure without transplantation In a recent paper published in the journal, scientists have discovered a new type of cell called hepatobiliary hybrid progenitor cells that form during early development in our uterus Surprisingly, there are also a small number of these cells in adults that can grow into adult livers, two major cell types of liver cells and bile duct cells have stem cell-like properties The team tested them in a similar way to mouse stem cells, which were found to repair the liver of mice quickly after severe damage such as cirrhosis Lead author Dr Dr Coe, from King's College London's Centre for Stem Cell and Regenerative Medicine, said: "For the first time, we have found that cells with true stem cell properties are likely to be present in the human liver This in turn could provide a wide range of regenerative medicine applications for the treatment of liver disease, including the possibility of bypassing the need for liver transplantation Liver disease is the fifth leading cause of premature death in the UK and the number of cases continues to rise It can be caused by lifestyle problems such as obesity, viruses, alcohol abuse, and non-lifestyle problems such as autoimmune and gene-mediated diseases "A major breakthrough! Scientists have successfully transplanted a pig's heart into a mole and kept her alive for several months: in a recent study published in the international journal, scientists from Germany, Sweden, Switzerland and the United States successfully transplanted a pig's heart into the body and kept the transplanted heart alive for a long time in the body; As the aging of the population in developed countries worsens, health care providers are facing increasingly serious human health problems such as how to deal with heart damage caused by heart disease The only treatment for such patients is to have a heart transplant but the number of patients who need a transplant each year is increasing and many patients waiting for transplants will die while they wait The solution to this problem is to breed animals that are anatomically similar to humans and use them to use their heart transplants to work on patients, but so far scientists have encountered many obstacles in this area of research, such as that the slugs that receive pig heart transplants rarely survive for more than a month Transplanting human brain cells into mouse brains helps to better understand neurological disorders such as Down syndrome: In a new study, researchers from the UK, Portugal and Switzerland transplanted human brain cells into the brains of mice to see for the first time how they grow and connect with each other This allows them to study the way human brain cells interact in a more natural environment than before Based on this technique, they built a model of Down syndrome using cells donated by two people with Down syndrome They also described the differencebetween between brain cells from people with Down syndrome and brain cells from people who did not have the disease They say their method could be used in the future to study a range of brain diseases, including schizophrenia and autism-related findings published in the journal Although some of the connections formed between brain cells in patients with Down syndrome are more stable and enriched, they communicate in a slightly incongruous manner This suggests that reduced coordination activity and increased stability in connections between brain cells in Down syndrome may be related to cognitive function Transplanting human brain cells into the brains of mice allows these researchers to monitor their maturation over time Eventually they found that brain cells from people with Down syndrome were not as active as normal cells at critical stages of development, which may have a significant impact on some of the symptoms of the disease () More wonderful counts! 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