never expected!

Chronic lymphocytic thyroiditis, also called "Hashimoto's thyroiditis" (HT), is the most common inflammatory autoimmune thyroid disease and the most common cause of hypothyroidism in areas with sufficient iodine
.

This disease is more common in women (the ratio of women to men exceeds 10:1)

80-90%

Rudolf Virchow first described the link between chronic inflammation and cancer in 1893
.

The relationship between HT and PTC was first described by Dailey et al.

A total of 4,785 studies were screened through a global database search
.

Finally, 50 studies were selected for qualitative synthesis, of which 27 were included in quantitative synthesis (Figure 1)

A total of 4,785 studies were screened through a global database search

1.
Papillary thyroid carcinoma

1.
Papillary thyroid carcinoma 1.
Papillary thyroid carcinoma

The included 45 studies investigated the possible relationship between HT and PTC
.

In these studies, the incidence of HT in PTC patients was 4.

The included 45 studies investigated the possible relationship between HT and PTC

2.

Thirteen studies evaluated the possible correlation between HT and follicular thyroid carcinoma (FTC)

3.

Six studies explored the possible role of HT in the occurrence of medullary thyroid carcinoma (MTC)

4.

Six studies investigated the relationship between HT and lymphoma.

5.
Undifferentiated thyroid cancer 5.
Undifferentiated thyroid cancer

Only two studies evaluated the relationship between undifferentiated thyroid cancer (ATC) and HT, and the incidence of TC in the HT group was 0 and 1.
02%, respectively
.
The meta-analysis reached 1.
92 OR (95% CI: 1.
90 ~ 0.
29; I2 test heterogeneity: 0%), and there was no statistically significant difference between the groups (p=0.
05)
.

Only two studies evaluated the relationship between undifferentiated thyroid cancer (ATC) and HT, and the incidence of TC in the HT group was 0 and 1.
02%, respectively
.
The meta-analysis reached 1.
92 OR (95% CI: 1.
90 ~ 0.
29; I2 test heterogeneity: 0%), and there was no statistically significant difference between the groups (p=0.
05)
.

6.
All cancer types

6.
All cancer types, all cancer types

The 27 studies had an appropriate control group that allowed us to calculate OR and include it in the meta-analysis
.
The result was 1.
36 OR (95% CI: 1.
05 ~ 1.
77; I2 test heterogeneity: 93.
66%).
There was a statistically significant difference in the incidence of TC between the case group and the control group (p=0.
01)
.

The 27 studies had an appropriate control group that allowed us to calculate OR and include it in the meta-analysis
.
The result was 1.
36 OR (95% CI: 1.
05 ~ 1.
77; I2 test heterogeneity: 93.
66%).
There was a statistically significant difference in the incidence of TC between the case group and the control group (p=0.
01)
.

In general, according to current knowledge, HT is related to thyroid malignancies, especially PTC, MTC, and lymphoma, but has nothing to do with ATC and FTC
.
In addition, this study found a significant association between HT and thyroid malignancies
.
High-RoB studies, high heterogeneity between different studies, and a limited number of design-based prospective studies make the available evidence uncertain, so more studies are needed to draw more reliable conclusions
.

In general, according to current knowledge, HT is related to thyroid malignancies, especially PTC, MTC, and lymphoma, but has nothing to do with ATC and FTC
.
In addition, this study found a significant association between HT and thyroid malignancies
.
In addition, this study found a significant association between HT and thyroid malignancies
.
High-RoB studies, high heterogeneity between different studies, and a limited number of design-based prospective studies make the available evidence uncertain, so more studies are needed to draw more reliable conclusions
.

 

Original source:

Abbasgholizadeh et al.
Is Hashimoto thyroiditis associated with increasing risk of thyroid malignancies? A systematic review and meta-analysis.
Thyroid Research (2021) 14:26
https://doi.
org/10.
1186/s13044-021-00117-x

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