Neuty: Intravenous thrombolytic therapy for patients with chronic kidney disease

Recently, a study published in the authoritative journal Neurology, the study aims to clarify the relationship between chronic kidney disease (CKD) and the safety and effectivenessof venous thrombolysomelicosis (IVT) in patients with acute ischemicstroke (AIS)researchers conducted a systematic review and tatter-based analysis of CKD patients who had received IVT to assess the following outcomes: symptomatic intracranial bleeding (sICH), asymptomatic and any intracranial bleeding (ICH), hospitalization and 3 months mortality, 3 months of good functional outcomes (FFO; improved Rankin scale (mRS) score 0-1) and 3 months of functional independence (FIRS0-2)CKD is defined as an estimate of renal glomerular filtration rate (eGFR) from mild (eGFR 60-89 mL/min) to moderate (eGFR for 30-59 mL/min) to severe (eGFR 15-29 mL/min)researchers identified 20 studies, including 60,486 AIS patients treated with IVTIn the uncorrected analysis, CKD and the National Institute of Neurological Disorders and Stroke (NINDS) (7 studies; ratio of 1.41, 95% confidence interval of 1.19-1.67) and European Cooperative Acute Stroke Study (ECASS) II (9 studies); OR is 1.37,95% CI is 1.01-1.85) defined as sICH, any ICH (8 studies; OR 1.42, 95% CI is 1.18-1.70), three-month mortality (9 studies; OR is 2.20, 95% CI is 1.72-2.81), 3-month FFO (8 studies); OR was 0.58, 95% CI was 0.47-0.72) and 3-month FI (8 studies; OR 0.57,95% CI was 0.46-0.71)In the correction analysis, CKD and according to NINDS (4 studies; OR is 1.34, 95% CI is 1.01-1.79) and ECASS II (3 studies; OR is 2.08, 95% CI is 1.27-3.43) defined sICH, any ICH (6 studies); OR is 1.41,95% CI In-hospital mortality (2 studies; OR 1.19,95% CI 1.09-1.30) and 3-month FFO (6 studies; OR 0.80,95% CI 0.70-0.92) were relatedit can be seen that moderate to severe CKD is associated with increased ICH risk and poor functional prognosis in AIS patients treated with IVT