Neuroticy: Polycortic atrophy in patients with multiple sclerosis increases cognitive decline

In order to verify the pathological process of accelerating cognitive impairment in the course of multiple sclerosis, this study used vertical MRI to study the cognitive decline of recurrent remission MS (RRMS) and progressive MS (PMS) diagnosticallyMethods This study included 230 MS patients and 59 healthy volunteers, of which 22 cases of RRMS patients were converted to PMS patientsThe longitudinal MRI data were used to calculate the rate of cortex and deep gray matter atrophy and lesions volume, and at the same time, cognitive decline was evaluated by cognitive scale and the correlation between the two was evaluatedResults There was no difference in the rate of deep gray matter atrophy in PMS and RRMS patients (-0.82%/year vs -0.71%/year, p-0.11), while PMS cortex shrinkage was faster than rrMS patients (-0.87%/vs -0.48%/year, p .01)Similarly, PATIENTS WITH PMS DECLINED MORE RAPIDLY IN COGNITIVE FUNCTION THAN RRMS PATIENTS (P0.01)Annual cognitive decline and stability RRMS patients increased lesions volume (r - 0.17, p - 0.03), converted RRMS patients with annual deep gray matter shrinkage rate (r s 0.50, p - 0.02) and PMS annual cortex shrinkage (r s 0.35, p s 0.01) were associatedConclusion The results of this study show that cortical atrophy and cognitive decline coexist in the MS processCognitive decline was reflected in the pathological change of local lesions in stable RRMS patients, in the patients with RRMS in transformation, was reflected in deep gray matter atrophy, and in PMS patients it was accelerated by cortex atrophy