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However, Huntington's disease has long been considered a neuronal disease, as demyelinating leads to the death of moderate spiny motor neurons, which ultimately leads to the characteristics of clinical progression of the disease: involuntary movements, impaired motor coordination, cognitive decline, depression, and psychosis
The new study, led by neuroscientist Steven Goldman, MD, Ph.
Goldman's lab previously found dysfunction
Next, the researchers isolated RNA and proteins from OPCs in the callosum, a thick bundle
Through the analysis of the gene network, the scientists targeted an inhibited transcription factor, Tcf7l2, which is key
The authors note that current research suggests that the causal relationship between transcription and myelin retention that relies on TCF7l2 provides an approachable mechanism
