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What is happiness? Leo Tolstoy said in "Anna Karenina" that happy people are all alike, unfortunate people are unfortunate in their own way, we constantly ask ourselves whether we are happy, but we want to be happy.
People often say that happy people use childhood to heal their whole life, and unfortunate people use their whole life to heal their childhood.
On January 18, 2022, Yu Xiang's research group from the School of Life Sciences, Peking University Joint Center for Life Sciences, and McGovern Institute for Brain Research, Peking University published online on Neuron entitled Social touch-like tactile stimulation activates a tachykinin1-oxytocin pathway To promote social interactions (the first author is the Center for Excellence in Brain Science and Intelligent Technology, Chinese Academy of Sciences)
Due to the large individual differences in the way mother mice care for their pups under natural conditions, and it is difficult to quantify, in order to analyze the neural circuits that regulate animal behavior in early tactile sensations, Yu Xiang's research group established a method of stroking early developmental mice.
Which neuron type in which brain region is primarily responsible for transmitting touch-sensing information to oxytocin neurons in the paraventricular nucleus? Combining rabies virus reverse tracing, brain slice electrophysiology, and optogenetics, we found that tachykinin type 1 (Tac1+) neurons located in the l/vlPAG receive projections from related brain regions in the classical somatic touch pathway, and have a direct response to the paraventricular nucleus.
Functionally, a series of electrophysiological, chemical genetics and behavioral experiments further elucidated that the l/vlPAG Tac1+ neuron-paraventricular nucleus oxytocin neuron pathway is sufficient and necessary to mediate the effects of early stroking
It has been reported in the literature that 90% of patients with autism spectrum disorder (Autism Spectrum Disorder, ASD) have sensory abnormalities
The research was completed under the guidance of researcher Yu Hang Yuxiang, a doctoral graduate of the Center for Excellence in Brain Science and Intelligent Technology of the Chinese Academy of Sciences, and Miao Wanying, a member of the research team, made important contributions to the research
