Neuron: Scientists have discovered a special cell type that is involved in the body's neuropathic pain-MRC1+ macrophages!

March 8, 2021 // One of the main signs of chronic pain is inflammation.

In the article, the researchers stated that stimulating the expression of an anti-inflammatory protein called CD163 may reduce signs of neuropathic inflammation in the spinal cord of mice with neuropathic pain.

Image source: Zylka Lab, UNC School of Medicine

According to US CDC data, about one-fifth of Americans suffer from chronic pain.

In this study, the researchers used single-cell RNA sequencing technology to analyze thousands of cells at a time to observe which cells have changed during chronic pain in the body, and which methods of cells have changed.

Researcher Niehaus said, this may be very interesting, because long-term inflammation of the spinal cord is very common in animal models of neuropathic pain; as the identity of the new type of macrophages has been elucidated, the researchers have also used a gene therapy to stimulate the MRC1+ giant The expression of an anti-inflammatory protein called CD163 in phages, based on this method, can reduce the inflammation of the host's spinal cord after one treatment, and can make this pain relief related behavior last up to one month.

One of the main signs of chronic pain is inflammation.

In the article, the researchers stated that stimulating the expression of an anti-inflammatory protein called CD163 may reduce signs of neuropathic inflammation in the spinal cord of mice with neuropathic pain.

According to US CDC data, about one-fifth of Americans suffer from chronic pain.

In this study, the researchers used single-cell RNA sequencing technology to analyze thousands of cells at a time to observe which cells have changed during chronic pain in the body, and which methods of cells have changed.

Researcher Niehaus said, this may be very interesting, because long-term inflammation of the spinal cord is very common in animal models of neuropathic pain; as the identity of the new type of macrophages has been elucidated, the researchers have also used a gene therapy to stimulate the MRC1+ giant The expression of an anti-inflammatory protein called CD163 in phages, based on this method, can reduce the inflammation of the host's spinal cord after one treatment, and can make this pain relief related behavior last up to one month.

Original source:

Laurence D Picton, Maria Bertuzzi, Irene Pallucchi, et al.