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News from March 20, 2021 //---Generally speaking, men and women have different responses and responses to pain, but scientists have not yet understood all the brain circuits related to these differences.
Now, new research in the laboratory of Dr.
Thomas Kash of the UNC School of Medicine shows that neurons use dopamine to regulate pain in male and female mice with different characteristics.
Now, new research in the laboratory of Dr.
Thomas Kash of the UNC School of Medicine shows that neurons use dopamine to regulate pain in male and female mice with different characteristics.
The findings, published in the journal Neuron, can help the scientific community design better pain management strategies, especially for women, who are most affected by pain throughout their lives.
(Image source:style="text-align: justify;">Professor Kash of pharmacology said: "The reason why we focused on this neural pathway is because our previous studies and other studies have shown that specific neurons release dopamine to regulate pain responses.
Unfortunately, this study is only in male children.
In mice.
Therefore, we decided to conduct research on male and female mice.
"
Unfortunately, this study is only in male children.
In mice.
Therefore, we decided to conduct research on male and female mice.
"
Dopamine, long known as the brain's pleasure chemical, can actually regulate a variety of behaviors.
It has previously been proven that dopamine neurons are important for both the beneficial properties and pain relief properties of heroin.
In addition, multiple studies have shown that these neurons can regulate attention, indicating that there is a link between drug abuse, pain and attention.
It has previously been proven that dopamine neurons are important for both the beneficial properties and pain relief properties of heroin.
In addition, multiple studies have shown that these neurons can regulate attention, indicating that there is a link between drug abuse, pain and attention.
Previously, the Kash laboratory used male mice to find that dopaminergic neurons play a key role in how opium reduces pain, possibly by releasing dopamine and glutamate.
In the new experiment, his laboratory focused on neural pathways starting from the midbrain region.
The dopamine-producing neurons in this area work together with the brain structure called the stria terminalis or BNST to form neural pathways.
In the new experiment, his laboratory focused on neural pathways starting from the midbrain region.
The dopamine-producing neurons in this area work together with the brain structure called the stria terminalis or BNST to form neural pathways.
"We found that activating this pathway reduces the pain sensitivity of male mice, but increases the sensitivity of female mice, especially when there is something that attracts their attention," the first author, Dr.
Waylin Yu, a former graduate student of Kashgar University Said: "We think this is because men and women respond differently to pain.
"
Waylin Yu, a former graduate student of Kashgar University Said: "We think this is because men and women respond differently to pain.
"
These experiments seem to indicate that dopamine can make males feel less painful, while in females, dopamine can help mice focus on other places in the event of pain.
Although more research is needed, Kash laboratory research shows that activating specific nerve projections of BNST can reduce acute and persistent inflammatory pain, further proving that dopamine signaling can enhance the blockade of painful stimuli, thereby counteracting severe pain.
(Bioon.
com)
(Bioon.
com)
Information source: com/news/2021-03-parsing-dopamine-pain-sensitivity-role.
html">Parsing dopamine's different pain sensitivity role in males, females
html">Parsing dopamine's different pain sensitivity role in males, females
Original link: Neuron (2021).
DOI: 10.
1016/j.
neuron.
2021.
03.
001
DOI: 10.
1016/j.
neuron.
2021.
03.
001
(Image source:style="text-align: justify;">Professor Kash of pharmacology said: "The reason why we focused on this neural pathway is because our previous studies and other studies have shown that specific neurons release dopamine to regulate pain responses.
Unfortunately, this study is only in male children.
In mice.
Therefore, we decided to conduct research on male and female mice.
"
Unfortunately, this study is only in male children.
In mice.
Therefore, we decided to conduct research on male and female mice.
"
Dopamine, long known as the brain's pleasure chemical, can actually regulate a variety of behaviors.
It has previously been proven that dopamine neurons are important for both the beneficial properties and pain relief properties of heroin.
In addition, multiple studies have shown that these neurons can regulate attention, indicating that there is a link between drug abuse, pain and attention.
It has previously been proven that dopamine neurons are important for both the beneficial properties and pain relief properties of heroin.
In addition, multiple studies have shown that these neurons can regulate attention, indicating that there is a link between drug abuse, pain and attention.
Previously, the Kash laboratory used male mice to find that dopaminergic neurons play a key role in how opium reduces pain, possibly by releasing dopamine and glutamate.
In the new experiment, his laboratory focused on neural pathways starting from the midbrain region.
The dopamine-producing neurons in this area work together with the brain structure called the stria terminalis or BNST to form neural pathways.
In the new experiment, his laboratory focused on neural pathways starting from the midbrain region.
The dopamine-producing neurons in this area work together with the brain structure called the stria terminalis or BNST to form neural pathways.
"We found that activating this pathway reduces the pain sensitivity of male mice, but increases the sensitivity of female mice, especially when there is something that attracts their attention," the first author, Dr.
Waylin Yu, a former graduate student of Kashgar University Said: "We think this is because men and women respond differently to pain.
"
Waylin Yu, a former graduate student of Kashgar University Said: "We think this is because men and women respond differently to pain.
"
These experiments seem to indicate that dopamine can make males feel less painful, while in females, dopamine can help mice focus on other places in the event of pain.
Although more research is needed, Kash laboratory research shows that activating specific nerve projections of BNST can reduce acute and persistent inflammatory pain, further proving that dopamine signaling can enhance the blockade of painful stimuli, thereby counteracting severe pain.
(Bioon.
com)
(Bioon.
com)
Information source: com/news/2021-03-parsing-dopamine-pain-sensitivity-role.
html">Parsing dopamine's different pain sensitivity role in males, females
html">Parsing dopamine's different pain sensitivity role in males, females
Original link: Neuron (2021).
DOI: 10.
1016/j.
neuron.
2021.
03.
001
DOI: 10.
1016/j.
neuron.
2021.
03.
001
(Image source: style="text-align: justify;">Professor Kash of pharmacology said: "The reason why we focused on this neural pathway is because our previous studies and other studies have shown that specific neurons release dopamine to regulate pain responses.
Unfortunately, this study is only in male children.
In mice.
Therefore, we decided to conduct research on male and female mice.
"
Unfortunately, this study is only in male children.
In mice.
Therefore, we decided to conduct research on male and female mice.
"
Dopamine, long known as the brain's pleasure chemical, can actually regulate a variety of behaviors.
It has previously been proven that dopamine neurons are important for both the beneficial properties and pain relief properties of heroin.
In addition, multiple studies have shown that these neurons can regulate attention, indicating that there is a link between drug abuse, pain and attention.
It has previously been proven that dopamine neurons are important for both the beneficial properties and pain relief properties of heroin.
In addition, multiple studies have shown that these neurons can regulate attention, indicating that there is a link between drug abuse, pain and attention.
Previously, the Kash laboratory used male mice to find that dopaminergic neurons play a key role in how opium reduces pain, possibly by releasing dopamine and glutamate.
In the new experiment, his laboratory focused on neural pathways starting from the midbrain region.
The dopamine-producing neurons in this area work together with the brain structure called the stria terminalis or BNST to form neural pathways.
In the new experiment, his laboratory focused on neural pathways starting from the midbrain region.
The dopamine-producing neurons in this area work together with the brain structure called the stria terminalis or BNST to form neural pathways.
"We found that activating this pathway reduces the pain sensitivity of male mice, but increases the sensitivity of female mice, especially when there is something that attracts their attention," the first author, Dr.
Waylin Yu, a former graduate student of Kashgar University Said: "We think this is because men and women respond differently to pain.
"
Waylin Yu, a former graduate student of Kashgar University Said: "We think this is because men and women respond differently to pain.
"
These experiments seem to indicate that dopamine can make males feel less painful, while in females, dopamine can help mice focus on other places in the event of pain.
Although more research is needed, Kash laboratory research shows that activating specific nerve projections of BNST can reduce acute and persistent inflammatory pain, further proving that dopamine signaling can enhance the blockade of painful stimuli, thereby counteracting severe pain.
(Bioon.
com)
(Bioon.
com)
Information source: com/news/2021-03-parsing-dopamine-pain-sensitivity-role.
html">Parsing dopamine's different pain sensitivity role in males, females
html">Parsing dopamine's different pain sensitivity role in males, females
Original link: Neuron (2021).
DOI: 10.
1016/j.
neuron.
2021.
03.
001
DOI: 10.
1016/j.
neuron.
2021.
03.
001
Dopamine, long known as the brain's pleasure chemical, can actually regulate a variety of behaviors.
It has previously been proven that dopamine neurons are important for both the beneficial properties and pain relief properties of heroin.
In addition, multiple studies have shown that these neurons can regulate attention, indicating that there is a link between drug abuse, pain and attention.
It has previously been proven that dopamine neurons are important for both the beneficial properties and pain relief properties of heroin.
In addition, multiple studies have shown that these neurons can regulate attention, indicating that there is a link between drug abuse, pain and attention.
Previously, the Kash laboratory used male mice to find that dopaminergic neurons play a key role in how opium reduces pain, possibly by releasing dopamine and glutamate.
In the new experiment, his laboratory focused on neural pathways starting from the midbrain region.
The dopamine-producing neurons in this area work together with the brain structure called the stria terminalis or BNST to form neural pathways.
In the new experiment, his laboratory focused on neural pathways starting from the midbrain region.
The dopamine-producing neurons in this area work together with the brain structure called the stria terminalis or BNST to form neural pathways.
"We found that activating this pathway reduces the pain sensitivity of male mice, but increases the sensitivity of female mice, especially when there is something that attracts their attention," the first author, Dr.
Waylin Yu, a former graduate student of Kashgar University Said: "We think this is because men and women respond differently to pain.
"
Waylin Yu, a former graduate student of Kashgar University Said: "We think this is because men and women respond differently to pain.
"
These experiments seem to indicate that dopamine can make males feel less painful, while in females, dopamine can help mice focus on other places in the event of pain.
Although more research is needed, Kash laboratory research shows that activating specific nerve projections of BNST can reduce acute and persistent inflammatory pain, further proving that dopamine signaling can enhance the blockade of painful stimuli, thereby counteracting severe pain.
(Bioon.
com)
(Bioon.
com)
Information source: com/news/2021-03-parsing-dopamine-pain-sensitivity-role.
html">Parsing dopamine's different pain sensitivity role in males, females
html">Parsing dopamine's different pain sensitivity role in males, females
Original link: Neuron (2021).
DOI: 10.
1016/j.
neuron.
2021.
03.
001
DOI: 10.
1016/j.
neuron.
2021.
03.
001
Previously, the Kash laboratory used male mice to find that dopaminergic neurons play a key role in how opium reduces pain, possibly by releasing dopamine and glutamate.
In the new experiment, his laboratory focused on neural pathways starting from the midbrain region.
The dopamine-producing neurons in this area work together with the brain structure called the stria terminalis or BNST to form neural pathways.
In the new experiment, his laboratory focused on neural pathways starting from the midbrain region.
The dopamine-producing neurons in this area work together with the brain structure called the stria terminalis or BNST to form neural pathways.
"We found that activating this pathway reduces the pain sensitivity of male mice, but increases the sensitivity of female mice, especially when there is something that attracts their attention," the first author, Dr.
Waylin Yu, a former graduate student of Kashgar University Said: "We think this is because men and women respond differently to pain.
"
Waylin Yu, a former graduate student of Kashgar University Said: "We think this is because men and women respond differently to pain.
"
These experiments seem to indicate that dopamine can make males feel less painful, while in females, dopamine can help mice focus on other places in the event of pain.
Although more research is needed, Kash laboratory research shows that activating specific nerve projections of BNST can reduce acute and persistent inflammatory pain, further proving that dopamine signaling can enhance the blockade of painful stimuli, thereby counteracting severe pain.
(Bioon.
com)
(Bioon.
com)
Information source: com/news/2021-03-parsing-dopamine-pain-sensitivity-role.
html">Parsing dopamine's different pain sensitivity role in males, females
html">Parsing dopamine's different pain sensitivity role in males, females
Original link: Neuron (2021).
DOI: 10.
1016/j.
neuron.
2021.
03.
001
DOI: 10.
1016/j.
neuron.
2021.
03.
001
"We found that activating this pathway reduces the pain sensitivity of male mice, but increases the sensitivity of female mice, especially when there is something that attracts their attention," the first author, Dr.
Waylin Yu, a former graduate student of Kashgar University Said: "We think this is because men and women respond differently to pain.
"
Waylin Yu, a former graduate student of Kashgar University Said: "We think this is because men and women respond differently to pain.
"
These experiments seem to indicate that dopamine can make males feel less painful, while in females, dopamine can help mice focus on other places in the event of pain.
Although more research is needed, Kash laboratory research shows that activating specific nerve projections of BNST can reduce acute and persistent inflammatory pain, further proving that dopamine signaling can enhance the blockade of painful stimuli, thereby counteracting severe pain.
(Bioon.
com)
(Bioon.
com)
Information source: com/news/2021-03-parsing-dopamine-pain-sensitivity-role.
html">Parsing dopamine's different pain sensitivity role in males, females
html">Parsing dopamine's different pain sensitivity role in males, females
Original link: Neuron (2021).
DOI: 10.
1016/j.
neuron.
2021.
03.
001
DOI: 10.
1016/j.
neuron.
2021.
03.
001
These experiments seem to indicate that dopamine can make males feel less painful, while in females, dopamine can help mice focus on other places in the event of pain.
Although more research is needed, Kash laboratory research shows that activating specific nerve projections of BNST can reduce acute and persistent inflammatory pain, further proving that dopamine signaling can enhance the blockade of painful stimuli, thereby counteracting severe pain.
(Bioon.
com)
(Bioon.
com)
Information source: com/news/2021-03-parsing-dopamine-pain-sensitivity-role.
html">Parsing dopamine's different pain sensitivity role in males, females
html">Parsing dopamine's different pain sensitivity role in males, females
Original link: Neuron (2021).
DOI: 10.
1016/j.
neuron.
2021.
03.
001
DOI: 10.
1016/j.
neuron.
2021.
03.
001
Although more research is needed, Kash laboratory research shows that activating specific nerve projections of BNST can reduce acute and persistent inflammatory pain, further proving that dopamine signaling can enhance the blockade of painful stimuli, thereby counteracting severe pain.
(Bioon.
com)
(Bioon.
com)
Information source: com/news/2021-03-parsing-dopamine-pain-sensitivity-role.
html">Parsing dopamine's different pain sensitivity role in males, females
html">Parsing dopamine's different pain sensitivity role in males, females
Original link: Neuron (2021).
DOI: 10.
1016/j.
neuron.
2021.
03.
001
DOI: 10.
1016/j.
neuron.
2021.
03.
001
Information source: com/news/2021-03-parsing-dopamine-pain-sensitivity-role.
html">Parsing dopamine's different pain sensitivity role in males, females
Information source: com/news/2021-03-parsing-dopamine-pain-sensitivity-role. html">Parsing dopamine's different pain sensitivity role in males, females
Original link: Neuron (2021).
DOI: 10.
1016/j.
neuron.
2021.
03.
001
DOI: 10.
1016/j.
neuron.
2021.
03.
001
html">Parsing dopamine's different pain sensitivity role in males, females
Original link: Neuron (2021).
DOI: 10.
1016/j.
neuron.
2021.
03.
001
DOI: 10.
1016/j.
neuron.
2021.
03.
001
Original link: Neuron (2021).
DOI: 10.
1016/j.
neuron.
2021.
03.
001
Original link: Neuron DOI: 10. DOI: 10.
1016/j.
neuron.
2021.
03.
001
1016/j.
neuron.
2021.
03.
001
