Neuron: Cell type-specific transcription reveals that mutated huntingnoproteinin (human and rat models) causes mitochondrial RNA release and neuronal inherent immune activation.

Huntington's disease is divided into five levels () that show no neuropathological abnormallevels showing the loss of striatum neurons and the level of striatum neurons lostIn addition to the number of lost striatum glial cells in neurons, the number of glial cells at the level also increased significantly although it is not fully understood how the repeated amplification of trinucleotides in the mutant Huntington gene () leads to the death of striatum neurons but is related to the acquisition and loss of toxic function, the effects of different cell processes (including synaptic nerve transmission, neuronutrient signaling, mitochondrial function, damage repair, axons and vesicle transport, calcium signaling and gene transcription)In order to obtain a resolution of a specific cell type in gene expression spectrum analysis, the authors reported the sequence characteristics of the tail-shell nucleus (striatum) cell type of the sample after death in humans to compare the mouse model data with the data obtained in the affected striatum neurons in humansA comparison of gene expression changes in mouse and human cell types revealed the complexity of previously unrecognized changes in the specific gene expression of the reaction to cell types and the preservation of changes in gene expression in neurons between mouse modelsMethods: The comparative study of mice models and human tissue samples revealed induced noncellular type specificity and cell type-specific reactionsThe large mice were used to represent the phenotype point in the early middle stagesAt this point in time more than one protein-encoded gene in double-stranded and in-the-middle disorder sorcing synopsies is a reaction to overexpression of external onsetResults: The study of unbiased gene expression in mouse models and human models not only created the first data set of cell type-specific molecular changes caused by various forms, but also revealed the inherent immune activation of mitochondrial release and neurons in the premiseOriginal origin: Original source: Original content presentation ends To determine whether the login is over.