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Cerebral small vessel disease (SVD) is a common disease in stroke patients and a common cause of stroke and vascular dementia .
Cerebral small vessel disease (SVD) is a common disease in stroke patients and a common cause of stroke and vascular dementia .
Una Clancy et al published a research article titled Impact of Small Vessel Disease Progression on Long-term Cognitive and Functional Changes After Stroke in NEUROLOGY to determine whether there is a correlation between WMH and cognitive ability and mRS score at different time points after stroke ; Whether associations differed by intra-individual trajectories ; whether longitudinal WMH volume changes were associated with changes in cognition and mRS , the main covariant endpoints ; and whether any associations were more strongly driving changes in cognition or mRS scores .
The study enrolled patients within 3 months of a minor ischemic stroke ( NIH Stroke Scale (NIHSS) score <8 , and is not expected to result in a modified Rankin Scale (mRS) score >2
The study enrolled patients within 3 months of a minor ischemic stroke ( NIH Stroke Scale (NIHSS) score <8 , and is not expected to result in a modified Rankin Scale (mRS) score >2
The research team recruited 264 patients; mean age was 66.
Cross-sectional correlation between ACE-R and mRS scores at (A) baseline, (B) 1-year and (C) 3-year follow-up
Cross-sectional correlation between ACE-R and mRS scores at (A) baseline, (B) 1-year and (C) 3-year follow-upThe main findings of the study are:
The main findings of the study are:- One year after stroke, standardized WMH volume was more associated with 1 - year ACE-R score ( β = –0.
This study showed that, after stroke , fluctuating changes in WMH mean that WMH volume 1 year after stroke is closely related to cognitive scores during the same period .
original sourceImpact of Small Vessel Disease Progression on Long-term Cognitive and Functional Changes After Stroke.
Impact of Small Vessel Disease Progression on Long-term Cognitive and Functional Changes After Stroke.
Neurology Apr 2022, 98 (14) e1459-e1469; DOI: 10.
1212/WNL.
0000000000200005 Impact of Small Vessel Disease Progression on Long-term Cognitive and Functional Changes After Stroke.
Neurology Apr 2022, 98 (14) e1459-e1469; DOI: 10.
1212/WNL.
0000000000200005
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