Neurology: Whether the postoperative effect of epilepsy is good or not depends on the location of the operation

Surgical treatment can cure temporal lobe epilepsy (TLE)
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Despite this, 30% to 40% of TLE patients will experience seizures and lose consciousness after surgery

Surgical treatment can cure temporal lobe epilepsy (TLE)

Ezequiel Gleichgerrcht et al.

 

The study included patients with drug-resistant temporal lobe epilepsy (TLE) from three epilepsy centers
.

Voxel-based and connected group-based mapping methods were used to determine the association between good results and surgically induced temporal lobe lesions

The study included patients with drug-resistant temporal lobe epilepsy (TLE) from three epilepsy centers

The cohort included 113 TLE patients [54 women; 16.

The degree of freedom of seizures after TLE is related to the following factors:

The degree of freedom of seizures after TLE is related to the following factors:

1) Surgical damage to hippocampus, amygdala piriform cortex complex and entorhinal cortex;

1) Surgical damage to hippocampus, amygdala piriform cortex complex and entorhinal cortex;

2) Absence of white matter tracts in the hook bundle, anterior commissure and fornix leads to disconnection of the temporal, frontal and marginal areas;

2) Absence of white matter tracts in the hook bundle, anterior commissure and fornix leads to disconnection of the temporal, frontal and marginal areas;

3) The frontal lobe (superior frontal gyrus and middle frontal gyrus, orbitofrontal area) and temporal lobe (upper pole and middle pole) are functionally disconnected
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3) The frontal lobe (superior frontal gyrus and middle frontal gyrus, orbitofrontal area) and temporal lobe (upper pole and middle pole) are functionally disconnected
.

A better degree of freedom of postoperative seizures is related to the surgical damage to the specific structures and connections of the entire temporal lobe
.

These findings reveal the key components of the epileptic network in TLE and provide promising new evidence for the improvement of future surgical interventions

A better degree of freedom of postoperative seizures is related to the surgical damage to the specific structures and connections of the entire temporal lobe

Association Between Anatomical Location of Surgically Induced Lesions and Postoperative Seizure Outcome in Temporal Lobe Epilepsy.

Association Between Anatomical Location of Surgically Induced Lesions and Postoperative Seizure Outcome in Temporal Lobe Epilepsy.
Neurology Oct 2021, 10.
1212/WNL.
0000000000013033; DOI: 10.
1212/WNL.
0000000000013033 Association Between Anatomical Location of Surgically Induced Lesions and Postoperative Seizure Outcome in Temporal Lobe Epilepsy .
Neurology Oct 2021, 10.
1212 / WNL.
0000000000013033 ; DOI: 10.
1212 / WNL.
0000000000013033 in this message