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Cases of dementia are expected to triple over the next 30 years, highlighting the importance of
identifying modifiable risk factors for dementia.
A study published today in Neurology aims to investigate whether adherence to routine dietary recommendations or a modified Mediterranean diet is associated with the subsequent development of dementia of all causes such as Alzheimer's disease (AD), vascular dementia (VaD), or future accumulation of AD-amyloid (A&# 946;) pathology
.
The baseline examination of the Swedish Population-Based Malmö Diet and Cancer Study (MDCS) was conducted between 1991 and 1996 and followed dementia events until 2014
.
Non-demented people born in 1923-1950 and living in Malmö were invited to participate
.
30,446 people were recruited (41% of all eligible persons).
28,025 people had dietary data and were included in this study
.
Eating habits were assessed
through a 7-day eating diary, a detailed food frequency questionnaire, and a 1-hour interview.
The primary outcome was occasional all-cause dementia, Alzheimer's disease, or vascular dementia as determined by the memory clinic doctor
.
The secondary outcome was A&946;- accumulation measured using cerebrospinal fluid (CSF) A&442 (n=738).
The COX proportional hazard model was used to examine the association between diet and risk of developing dementia (adjusted for demographics, comorbidities, smoking, physical activity and alcohol).
In this 20-year follow-up study, either following routine dietary recommendations or a modified Mediterranean diet was significantly associated with
a reduced risk of subsequent development of all-cause dementia, AD dementia, VaD, or AD pathology.
Sources:
Glans I, Sonestedt E, Nägga K, et al.
Association Between Dietary Habits in Midlife With Dementia Incidence Over a 20-Year Period [published online ahead of print, 2022 Oct 12].
Neurology.
2022; 10.
1212/WNL.
0000000000201336.
doi:10.
1212/WNL.
0000000000201336