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Neurology: The efficacy of metoclopramide combined with diphenhydramine in the treatment of acute post-traumatic headache

 Last Update: 2021-04-13
 Source: Internet
 Author: User

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It is not uncommon for people experiencing concussions to experience moderate to severe headaches within a few weeks after the injury.

Metoclopramide ( metoclopramide, Metoclopramide) is a common clinical antiemetics, it has found that the drug can be used for the treatment of medsci.

Diphenhydramine is a common antihistamine, which has antihistamine H1 receptor effect, has a strong inhibitory effect on the central nervous system, and has atropine-like effect.

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Intravenous injection of large doses of metoclopramide can cause restlessness, so this study combined diphenhydramine and metoclopramide to prevent these adverse symptoms.

The study finally included 160 people who had experienced head trauma.

The study found that the combined medication group reduced the pain of ordinary people by more than 5 points after one hour.

The lead author of the study, Friedman, said: "This study provides Class I evidence for patients with acute, moderate or severe post-traumatic headaches.

References: References: References:Randomized Study of Metoclopramide Plus Diphenhydramine for Acute Posttraumatic HeadacheNeurologydoi.
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