Neurology: PET's new image score can help predict the risk of Alzheimer's disease

The initial diagnosis of Alzheimer's disease (AD) was based only on clinical symptoms and recently changed from syndrome to biological assessment.
AT(N) is a framework for research proposed by the National Institute on Aging and the Alzheimer's Society, and is based on imaging and bioflow biomarkers.
The framework defines three biomarkers: biomarkers of neuropathy, including markers of A-beta plaques (labeled "A"), fiber tau (labeled "T"), and biomarkers of neurodegeneration or neuron damage.
(N)", whose two-value results in different biomarkers "profiles".
in the AT(N) framework: AD is biologically defined by neuropathological markers, and neurodegeneration and subsequent cognitive impairment are seen as the after-effects and symptoms of the disease, not as a definition of the disease.
therefore, the diagnosis of live AD, whether beta (A) or pathological tau (T) must be abnormal, regardless of clinical symptoms.
addition to its diagnostic value, the AT(N) program is particularly valuable for subjects with mild cognitive impairment because it provides prognostion information about the risk of DEVELOPing MCI to AD dementia.
unlike neuropathological biomarkers A and T, biomarkers of neurodegeneration or neuron damage are not necessary for diagnosis of AD.
(N) biomarkers are mostly nonse specific to AD-induced neurodegeneration, indicating neuron damage of different egenes, which limits the accuracy of its diagnosis.
neurodegenerative biomarkers proposed by the
AT(N) framework include 2-deoxygenation-2-(18F) fluorine-D-glucose (18F) FDG) PET for low metabolism, sea mass atrophy, total tau (T-tau) abnormality in CSF, axon protein nerve strand (NfL) in plasma.
Ganna Blazhenets of the University of Freiburg, Germany, and others, based on Alzheimer's Disease Neuroimaging Initiative (ADNI), have recently proposed an AD Dementia Conversion-Related Pattern (Alzheimer Dementia Dementia-Related Pattern, ADCRP) that distinguishes between MCI and AD dementia converters and non-converters.
they were included in 269 subjects who received the FDG PET (which can be indirectly used to quantify ADCRP scores), the AV-45 PET, and the detection of phosphate and total tau in CSF and neural wire light chain NfL in plasma.
According to the AT(N) classification scheme, Alzheimer's disease is defined by in vivo A beta deposition ("A") and pathological tau ("T") biomarkers, and subjects are divided into groups A-T-, A-T-, A-T-,A-T-T-
results showed that the average ADRP subject scored ADCRP and the average subject score was significantly higher than the other groups (P<0.05) in the A-T-group, but the between the companies was similar (average P>0.1).
in the A-T-group, the ADCRP score is a significant predictor of dementia (for each additional z-score, HR is 2.02, p<0.001), and its predictive value is higher than that of other biomarkers of neurodegeneration (total tau and NfL).
significance of this study is the discovery that the ADCRP score is a valuable biomarker of neurodegeneration, the subject of mild cognitive impairment and biologically defined Alzheimer's disease.
it shows great potential for risk stratiferation and predictive transformation into dementia for mild cognitive impairment and underlying Alzheimer's disease (A-T-plus).
origins: Blazhenets, G., Frings, L., Ma, Y., Sörensen, A., Eidelberg, D., Wiltfang, J., ... & Alzheimer’s Disease Neuroimaging Initiative. Validation of the Alzheimer Disease Dementia Conversion-Related Pattern as an ATN Biomarker of Neurodegeneration. _Neurology_. Freeman Source: MedSci Original Copyright Notice: All text, images and audio and video materials on this website that indicate "Source: Mets Medicine" or "Source: MedSci Originals" are owned by Mets Medical and are not reproduced by any media, website or individual without authorization, and are authorized to be reproduced with the words "Source: Mets Medicine".
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