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Arterial ischemic stroke in children is a rare event but is associated with an increased risk of cognitive and neurological sequelae
.
The identification of factors associated with poor prognosis has been a focus of research for many years; however, research on prognosis prediction is still insufficient
Pediatric Arterial Ischemic Stroke Pediatric Stroke
Due to the rapid synaptogenesis and increased processes of myelination and reorganization of neuronal networks during this period, it is suggested that the developing brain is more flexible and resilient after early brain injury
.
On the other hand, the developing brain is particularly vulnerable to early brain damage, which disrupts brain development
Although several studies have examined cognitive outcomes in the acute phase up to two years after stroke, studies investigating outcomes in patients with advanced chronicity (>2 years after stroke) have been limited
.
Focusing on patients who are chronically advanced is critical, as deficits can develop over time and increase the recovery process, possibly well beyond the first few months after a stroke
Quality of life Recently, researchers examined long-term cognitive outcomes after stroke in children in the chronic phase (more than 2 years after stroke) and investigated whether age affects cognition in stroke to determine the risk of patients with poorer cognitive outcomes.
This cross-sectional study included chronic-phase stroke patients (more than 2 years after stroke) and controls with previously diagnosed neonatal or childhood arterial ischemic stroke
.
Participants with active epilepsy, severe learning difficulties, or behavioral problems hindering cognitive assessment were excluded
diagnosis
- Fifty-two neonatal or pediatric patients with arterial ischemic stroke (median age: 15.
3 years, IQR=10.
6-18.
7) and 49 healthy controls (median age: 13.
6 years, IQR=9.
8-17.
2) met the inclusion criteria
. - Cognitive outcomes were significantly worse in the childhood stroke group compared with the control group
. - The nonlinear effects of age at stroke (independent of lesion size and location) on cognitive flexibility, processing speed, and language learning showed significant significance in early childhood stroke (29 days to <6 years)
.
Cognitive outcomes were worse (p<0.
Stroke age is an important factor in post-stroke recovery and moderates long-term cognitive outcomes, independent of lesion size and lesion location
Abgottspon S, Thaqi Q, Steiner L, et al.
Impact of Age at Pediatric Stroke on Long-term Cognitive Outcome [published online ahead of print, 2021 Dec 16].
Neurology.
2021;10.
1212/WNL.
0000000000013207.
doi:10.
1212/ WNL.
0000000000013207 Leave a message here
