Neurology: Parkinson's disease, insufficient exercise of cognitive function, or dementia

People with Parkinson's disease (PD) had an almost 6-fold increased risk of developing cognitive impairment and dementia (PDD) compared to age-matched

Figure 1: Cover art of the paper

However, 24% of patients with PD-MCI returned to normal cognitive function

To date, studies have shown that progress in IADL is associated with a deterioration in some cognitive indicators and future cognitive test performance, but the results predicting cognitive diagnosis are uncertain due to the lack of longitudinal studies

On the cross-section, not all studies have confirmed a direct link between cognition and function in PD,10,11 which means that not all instruments are suitable for detecting cognitive-driven IADLs and may be confused

They hypothesized that patients with both PD-MCI and cognitive IADL disorders had a higher

First: define the baseline phenotype associated with cognitive IADL impairment, with the expectation of decreased cognitive performance, genetic risk variants associated with cognitive impairment, and high ratios of cerebrospinal fluid (CSF) biomarkers;

Figure 2: Graph of the paper results

Second: The study studied the progress of functions over time reflected by changes in FAQ subscores, assuming that patients with baseline classification of PD-MCI or cognitive IADL disorder had higher

They conducted an observational longitudinal study using cognitive and clinical scores, as well as genetic and CSF biomarkers

Of the 268 PD patients assessed at baseline, 108 (40.

HR with baseline cognitive IADL disorder (n=37) to dementia was described as higher than PD-MCI, but highest among patients with both markers (HR=12.

In the follow-up sample, nearly half of the patients (n=10, 47.

Becker S, Bode M, Brockmann K, et al.