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Neurology: Mechanisms of beta-amyloidosis implicated in Alzheimer's disease, dementia with Lewy bodies, coexisting localized beta-amyloid and cortical atrophy interactions

 Last Update: 2022-02-20
 Source: Internet
 Author: User

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Basal forebrain (BF) In neurodegenerative diseases, BF cholinergic neurons often degenerate, leading to subsequent cognitive decline

β-Amyloid BF atrophy α-synuclein cholinergic deficiency Since cortical atrophy can reflect the pathological spreading pattern of AD and LBD, a comparative assessment of cortical thinning patterns associated with cholinergic atrophy and β-amyloid burden has Helps understand the two most common neurodegenerative diseases

^18F -flubetabine positron emission tomography with BF volume and cortical thickness (CTH) and β-amyloid load obtained by magnetic resonance imaging (MRI), neuropsychological assessment of cognitive function.

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BF volume mediates the association of FBB-SUVR with cortical thickness in AD and LBD disease spectrum, whereas FBB-SUVR is associated with CTH independently of BF volume only in LBD disease spectrum

There are common β-amyloidosis mechanisms in AD and LBD spectrum, with or without BF mediation, BF atrophy is more profoundly related to cognitive impairment, and localized β-amyloid is present in LBD disease spectrum and cortical atrophy

Yoo HS, Jeon S, Cavedo E, et al.
Association of β-Amyloid and Basal Forebrain With Cortical Thickness and Cognition in Alzheimer and Lewy Body Disease Spectra [published online ahead of print, 2021 Dec 30].
Neurology.
2021;10.
1212/ WNL.
0000000000013277.
doi:10.
1212/WNL.
0000000000013277Leave

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