Neurology: In patients with multiple sclerosis, depression may increase the risk of vascular disease and death

Previous studies have shown that depression is the most common comorbidity in patients with multiple sclerosis (MS), affecting 21-24% of MS patients at any given point in time

In the general population, depression is associated with an increased relative risk of vascular disease (30%) and an increased relative risk of death from all causes (70%)

A Danish study found that comorbid psychosis, including bipolar disorder and psychosis, was associated with an increase in all-cause mortality, but did not include a control group, so it is uncertain whether the degree of this association is different from that of the general population

A Canadian research report shows that multiple sclerosis and depression have a greater impact on mortality from all causes than the additive effect

In this way, Raffaele Palladino of Imperial College London and others evaluated whether the associations between depression, vascular disease, and mortality are different in patients with multiple sclerosis compared with a control group matched by age, sex, and general doctors

They conducted a population-based retrospective matched cohort study between January 1, 1987 and September 30, 2018, which included patients with multiple sclerosis in England and matched controls without multiple sclerosis, according to depression The symptom status is stratified

12,251 multiple sclerosis patients and 72,572 matched controls were identified

The 10-year risk of death from all causes for controls with depression was 1.

In general, the interaction between multiple sclerosis status and depression is synergistic, and 14% of the observed effects can be attributed to this interaction