Neurology: In patients with mild cognitive impairment, amyloid-β deposits were lower and dopamine activity decreased

Mild Cognitive Impairment (MCI) combined with one or more of the core characteristics of dementia and louisomes (DLB) represents a transitional phase that can progress to clinically likely DLB.
recently, academically defined it as a key forward DLB pelet (MCI-LB).
the use of imaging student markers facilitates early detection of DLB, and identifying patients during the MCI-LB phase provides an opportunity to provide early intervention.
In Louisian disease, α-synuclein pathological deposition is an important manifestation, while many patients also have varying degrees of amyloid pathological manifestations, which may contribute to the onset of DLB.
lewy-related pathology and amyloid-β pathology, which are present at the same time, affect the clinical performance of the DLB pre-drive period.
increased amyloid-β burden on Pittsburgh complex-B (PiB) PET was reported in more than half of DLB patients and associated with greater cognitive impairment in DLB.
123I-FP-CIT SPECT (quantitative dopamine transporter) before death can distinguish BETWEEN diseases confirmed by autopsies.
this supports 123I-FP-CIT SPECT as a biomarker of basic Lewy-related pathology in MCI-LB.
, Qin Chen and others at Huaxi Hospital, Sichuan University, explored the relationship between amyloid-β-PET and dopamine transporter imaging (123I-FP-CIT SPECT) and clinical ideotypes in MCI-LB patients.
they were included in (n-34) MCI-LB patients, who were divided into β-amyloid A-plus or A-groups, and 123I-FP-CIT SPECT D-plus or D-groups, based on previous literature.
is divided into four subgroups: A-D-, A-D-, A-D, or A-D-.
the relationship between grading and clinical esophysiosis through the quantitative scoring of pathology.
results showed that the relationship between A-D-plus biomarkers and patient characteristics was most common (38.2%), followed by A-D-plus (26.5%) and A-D-plus (26.5%).
least common is the A-D-biomarker spectrum (8.8%).
the older group, the frequency of APOE 4 carriers is higher, and the MMSE score is lower than that of group A-group.
are more likely to have rapid eye movement sleep behavior disorders in the D-plus group.
Lower PiB SUVRs were independently associated with a higher Unified Parkinson's Disease Score Sheet (UPDRS)-III score.
significance of the study is the finding that most people with MCI-LB have a higher Updrinson's Disease Uniform Score (UPDRS-III) score.
most MCI-LB patients are characterized by less amyloid-β deposition and reduced dopamine activity.
amyloid-β PET and 123I-FP-CIT SPECT complement each other in describing clinical esoploids in MCI-LB patients.
Origins: Chen, Q., Lowe, V. J., Boeve, B. F., Przybelski, S. A., Miyagawa, T., Senjem, M.L., Jack, C. R., Jr., Lesnick, T. G., Kremers, W.K., Fields, J.A., Min, H.K., Schwarz, C.G., Gunter, J.L., Graff-Radford, J., Savica, R., Knopman, D.S., Jones, D., Ferman, T.J., Graff-Radford, N.R., Petersen, R.C.... Kantarci, K. (2021). Mild Cognitive Impairment at Risk for Lewy Body Dementia. _Neurology_, 10.1212/WNL.0000000000011454. Advance online publication. Freeman Source: MedSci Original Copyright Notice: All text, images and audio and video materials on this website that indicate "Source: Mets Medicine" or "Source: MedSci Originals" are owned by Mets Medical and are not reproduced by any media, website or individual without authorization, and are authorized to be reproduced with the words "Source: Mets Medicine".
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