Neurology: identification of inflammatory markers associated with dementia

December 13, 2019 / Biovalley bio on / - recently, a research report published in the international journal Neurology, scientists from the University of Texas Health Science Center found that the inflammatory markers named sCD14 were directly related to brain atrophy, cognitive decline and dementia Photo source: cc0 public domain this study is based on two large community-based heart studies involving 4700 participants, researcher Sudha According to Seshadri, sCD14 may be a useful marker for assessing the risk of cognitive decline and dementia in individuals, and what excites researchers most is that if there is time to intervene or change a person's life process, they may be able to assess their risk in advance The researchers said that high levels of sCD14 were directly related to indicators of brain aging and injury, such as overall brain atrophy and decreased executive function In this paper, the researchers studied 1588 participants from the Framingham Heart Research Program and 3129 participants from the cardiovascular health research program The researchers studied the indicators in the blood plasma of participants SCD14 was measured In the Framingham group, the researchers tested the brain MRI and cognitive function of the participants within one year of measuring the level of sCD14 in the body, and then carried out the second round of testing seven years later The average time of monitoring dementia was nine years In the cardiovascular health research program, the researchers scanned the brain MRI of the newly recruited participants and 5 years later respectively; the researchers pointed out that the biomarkers based on blood and cost-effective Often it can help to detect and track the progress of preclinical brain damage in patients who are prone to develop dementia; such markers may be able to be the focus of clinical trials of disease modification intervention, and help expand researchers' understanding of disease biology At present, researchers have not carried out any drug trials to see whether reducing the level of sCD14 can help improve human cognitive ability However, the use of a variety of targeted anti-inflammatory drugs (such as statins) may reduce the level of sCD14 At present, researchers are increasingly aware of the decline of inflammatory cognitive function related to neurodegenerative diseases and vascular damage And dementia play a key role in the pathogenesis, later they need to conduct more in-depth research to clarify the specific molecular mechanism Original source: Matthew P pase, jayandra J himali, Alexa s Beiser, et al Association of CD14 with incident dementia and markets of brain aging and investment, Neurology (2019) Doi: 10.1212/wnl.0000000000008682