Neurology: Global prevalence and prevalence of optic neurospinalitis

Since the last epidemiological review of optic neurosomalitis/optic neurospinalitis spectrum disease (NMO/NMOSD), 22 related studies have been published.
recently, researchers systematically reviewed the global prevalence, incidence, and basic demographic characteristics of NMOSD in a research paper published in Neurology, an authoritative journal in the field of neurology, and provided an important overview of the study.
researchers searched the PubMed, Ovid Medline, and EMBASE databases from 1999 to August 2019 using medical theme words and keywords, as well as a list of references to the retrieved articles.
researchers collected data on national, regional, case assessment methods and water channel protein-4 antibody (AQP4-Ab) testing, study periods, limitations, morbidity (per 100,000 people per year), prevalence (per 100,000 population), age, gender and race-specific morbidity or prevalence.
researchers identified 33 related articles, which showed that in the African-Caribbean region, the incidence and prevalence of NMOSD was highest in the region(0.73/100,000 people per year (95% CI:0.45-1.01) and 10/100,000 (95% CI:6.8-13.2).
NMOSD has the lowest rates in Australia and New Zealand (0.037/1000000 people per year (95% CI: 0.036-0.038) and 0.7/1000000 (95% CI:0.66-0.74).
women are dominant in adults and in the AQP4-Ab sero-positive subst group.
prevalence and prevalence rates peak among middle-age adults.
incidence and prevalence of NMOSD among African-Americans, while whites had the lowest prevalence.
over time, no significant pathogenesis trends were found.
shows that NMOSD is a rare disease around the world.
the analysis has described differences in prevalence and incidence between geographical regions and races.
these are only partially explained by different research methods and NMO/NMOSD definitions, highlighting the need for specially designed epidemiological studies to identify genetic effects and causes.
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