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Several clinical signs of Parkinson's disease (PD), such as predominant tremor, postural instability and gait difficulty, rapid eye movement sleep behavior disorder, cognitive impairment, and autonomic dysfunction, are thought to constitute Different disease phenotypes have different prognosis and treatment response
.
Hypodynamic dysarthria, which is found in up to 90% of patients during the progression of the disease, is characterized by single pitch, reduced pressure, monotony, imprecise consonants, inappropriate silence, harsh wheezing, and abnormal voice timing
Hypodynamic dysarthria, which is found in up to 90% of patients during the progression of the disease, is characterized by single pitch, reduced pressure, monotony, imprecise consonants, inappropriate silence, harsh wheezing, and abnormal voice timing
Recently, researchers have determined the speech subtypes of patients with Parkinson's disease after treatment and checked their response to long-term dopaminergic treatment
The researchers recorded the voice data of 111 Parkinson's disease patients, 83 of whom completed a 12-month follow-up (69 Parkinson's disease patients received stable dopaminergic treatment, 14 untreated Parkinson's disease Patient)
.
Unsupervised k-means cluster analysis was performed on the eight characteristic parameters of motor dysarthria examined by quantitative acoustic analysis
- Three different speech subtypes were detected with similar prevalence, symptom duration, and exercise severity: "prosody subtype", "speech subtype" and "speech subtype"
. - In addition to the common monophonic and monochromatic subtypes, the speech subtypes with difficulty in pronunciation and the pronunciation subtypes with inaccurate pronunciation of consonants are more serious than the prosodic subtypes
. - Clinically, the prosody subtype is characterized by more women and younger age, while the pronunciation subtype is more common in men, older age, heavier axial gait symptoms, and poor cognitive ability
.
The speech subtype represents the intermediate state of age clinically, most of which are men, and cognitive ability is preserved
Different language disorder phenotypes of patients with new-onset Parkinson's disease reflect different underlying mechanisms and can predict the response of language disorder to levodopa treatment
https://n.
neurology.
org/content/early/2021/10/04/WNL.
0000000000012878.
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