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Neurology: Cognitive Outcomes 1 Year After Mild Traumatic Brain Injury: Results from the TRACK-TBI Study

 Last Update: 2022-04-23
 Source: Internet
 Author: User

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Mild traumatic brain injury (mTBI) affects tens of millions of people worldwide each year and is an emerging risk factor for dementia
.

Current research has focused on unraveling the mechanisms underlying this long-term adverse cognitive outcome, but little attention has been paid to characterizing short-term cognitive outcomes (ie, within 1 year) after mTBI

Mild traumatic brain injury (mTBI) affects tens of millions of people worldwide each year and is an emerging risk factor for dementia

Consensus Cognitive Impairment This limitation of the existing literature on cognitive decline highlights the need to develop a definition of post-TBI cognitive outcomes that combines clinically relevant, patient-centered definitions of cognitive impairment and cognitive decline

We conducted a multicenter study of 1-year outcomes in patients with acute traumatic brain injury seen in a level 1 trauma center

The study was a prospective cohort study of 656 participants aged 17 and older who presented to a level 1 trauma center within 24 hours of mTBI (Glasgow Coma Scale [GCS] 13-15), 156 were demographically similar of healthy controls enrolled in the Translational Research and Clinical Knowledge of Brain Injury (Track-TBI) study
.

Poor 1-year cognitive outcome was defined as cognitive impairment (≥2 standard data on cognitive tests).

The mean age of mTBI patients was 40.
2 years, 36.
6% were female, and 76.
6% were white
.
Poorer 1-year cognitive outcomes were associated with worse 1-year functional outcomes, more neurobehavioral symptoms, greater psychological distress, and lower life satisfaction (all P<0.
05), establishing concurrent validity
.
After 1 year, 13.
5% of participants with mild traumatic brain injury had poorer cognitive function, compared with 4.
5% in the control group, p=0.
003
.
In univariate analysis, poor 1-year cognitive outcomes were associated with nonwhite race, low education, low income, lack of health insurance, hyperglycemia, pre-injury depression, and injury severity (all P<0.
05)
.
The final multivariate predictive model included education, health insurance, pre-injury depression, hyperglycemia, and Rotterdam CT score >3, with an AUC of 0.
69 (95%CI=0.
62-0.
75) for predicting poor one-year cognitive outcomes, with each variable associated with A >2-fold increase in odds of adverse one-year cognitive outcomes was associated
.

The mean age of mTBI patients was 40.
2 years, 36.
6% were female, and 76.
6% were white
.

Poorer 1-year cognitive outcomes were associated with worse 1-year functional outcomes, more neurobehavioral symptoms, greater psychological distress, and lower life satisfaction (all P<0.
05), establishing concurrent validity
.

After 1 year, 13.

Poor one-year cognitive outcomes were common, affecting 13.

Christman Schneider AL, Huie JR, Boscardin WJ, et al.

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