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At present, focal epilepsy is widely regarded as a network disorder; according to this, focal lesions can cause widespread abnormalities in the brain network
.
The conceptualization of these epilepsy networks is primarily driven by evidence of temporal lobe epilepsy; however, recent studies have shown that focal cortical dysplasia (FCD) may also be characterized by extensive functional network abnormalities
At present, focal epilepsy is widely regarded as a network disorder; according to this, focal lesions can cause widespread abnormalities in the brain network
Groove floor dysplasia (BOSD) is a type of FCD with unique neuropathological and neuroimaging characteristics
Recently, researchers have applied a technique called fixation-based analysis (FBA), which can identify specific white matter structures that exhibit clinically important structural connectivity reduction, thereby identifying the floor of the sulci The structure of white matter fiber tracts in patients with dysplasia (BOSD) is abnormal, and its relationship with seizure activity is discussed
The diffusion magnetic resonance imaging data was analyzed based on whole brain fixation to determine that the fiber density and cross-section of white matter fiber tracts in BOSD patients (n=20) were significantly reduced compared with healthy control participants (n=40)
.
Using the results of whole brain analysis as a priori, the relationship between abnormal fiber bundles and the frequency and duration of seizures was explored
The diffusion magnetic resonance imaging data was analyzed based on whole brain fixation to determine that the fiber density and cross-section of white matter fiber tracts in BOSD patients (n=20) were significantly reduced compared with healthy control participants (n=40)
- Although the dysplasia is focal, BOSD patients show a wide range of white matter fiber tract abnormalities, including bilateral corticospinal, corticothalamus and hypothalamic tracts, superior longitudinal tract, corpus callosum (body), and corpus callosum radiation line occipital
.
This pattern of reduced bilateral connectivity has nothing to do with the laterality of the lesion
Research has proved that the bilaterally distributed, specific white matter network is susceptible to interference in BOSD
Literature source: M too R, Vaughan DN, Semmelroch M, Connelly A, Jackson GD.
Bilateral Structural Network Abnormalities in Epilepsy Associated With Bottom-of-Sulcus Dysplasia [published online ahead of print, 2021 Oct 21].
Neurology.
2021;10.
1212 /WNL.
0000000000013006.
doi:10.
1212/WNL.
0000000000013006 Literature source: M too R, Vaughan DN, Semmelroch M, Connelly A, Jackson GD.
Bilateral Structural Network Abnormalities in Epilepsy Associated With Bottom-of-Sulcus Dysplasia [published online ahead of print, 2021 Oct 21].
Neurology.
2021;10.
1212/WNL.
0000000000013006.
doi:10.
1212/WNL.
0000000000013006ito R, Vaughan DN, Semmelroch M, Connelly A, Jackson GD.
Bilateral Structural Network Abnormalities in Epilepsy Associated With Bottom-of-Sulcus Dysplasia [published online ahead of print, 2021 Oct 21].
Neurology.
2021;10.
1212/WNL.
0000000000013006 .
doi:10.
1212/WNL.
0000000000013006 leave a message here
