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Neurology: Attention people with family history!

 Last Update: 2021-12-24
 Source: Internet
 Author: User

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Cerebral aneurysm (cerebral aneurysm) is due to the fragility of the arterial walls of the brain and other reasons, causing the blood vessel walls to form congenital tumor-like objects, so they are called cerebral aneurysms
.

The blood vessel wall in an aneurysm is relatively easy to rupture because of the lack of the media.

Many cerebral aneurysms are located in the subarachnoid space, so this disease is the biggest cause of subarachnoid hemorrhage.

The American Heart Association scientific statement once pointed out that the duration and quality of sleep have an impact on life>

In this IPD meta-analysis, researchers conducted Embase and PubMed searches to find studies published as of December 1, 2020
.

The following studies were included:

(1) Have a forward-looking research design;

(2) Including 50 or more patients with aneurysm;

(3) To study the natural process of aneurysm and risk factors for aneurysm rupture, including family history of aneurysm subarachnoid hemorrhage and UIA;

(4) The rupture of the aneurysm is one of the results
.

The queues with IPD are included

(1) Have a forward-looking research design;

(2) Including 50 or more patients with aneurysm;

(3) To study the natural process of aneurysm and risk factors for aneurysm rupture, including family history of aneurysm subarachnoid hemorrhage and UIA;

(4) The rupture of the aneurysm is one of the results
.

The queues with IPD are included

The results included a total of 8 cohorts of IPD
.

In the 6 cohorts, first-degree relatives were defined as parents, siblings, and children (29% were Dutch, 55% were Finns, and 15% were Japanese), with a total of 2297 patients (17% were familial, 399 Patients), there were 3089 cases of aneurysms, followed up for 7301 person-years

Overall, the risk of rupture in familial cases increased by 156% (HR=2.
56; 95%CI 1.
18-5.
56)
.

After joining two cohorts that excluded siblings as first-degree relatives, analysis of 9511 participants found that the risk of familial cases was still increased by 44% (HR=1.

Overall, the risk of rupture in familial cases increased by 156% (HR=2.

During follow-up, the risk of rupture in familial and sporadic patients

In summary, the risk of familial aneurysm rupture is 2.
5 times higher than that of sporadic aneurysm.
Therefore, family history should be considered when assessing the risk of aneurysm rupture
.

In summary, the risk of familial aneurysm rupture is 2.

references:

Difference in Rupture Risk Between Familial and Sporadic Intracranial Aneurysms An Individual Patient Data Meta-analysis.
Neurology Nov 2021, 97 (22) e2195-e2203; DOI: 10.
1212/WNL.
0000000000012885

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