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Neurology: Association of cognitive impairment with free water (FW) in Meynert's basal and locus coeruleus to the entorhinal cortex

 Last Update: 2022-01-23
 Source: Internet
 Author: User

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Extracellular amyloid beta aggregates and intracellular tau lesions are pathological features of AD

To determine the relationship between diffuse microarchitecture and early changes in Alzheimer's disease (AD) severity, assessed by clinical diagnosis, cognitive performance, dementia severity, and plasma neurofilament light chain concentrations

In the locus coeruleus-olfactory cortex tract, Meynert basal ganglia and hippocampus, the FW of the EMCI group was significantly higher than that of the CN group (mean Cohen d=0.

The results showed that higher FW was associated with more severe clinical diagnosis, cognitive impairment and neurofilament light chain

Chu WT, Wang WE, Zaborszky L, et al.
Association of Cognitive Impairment With Free Water in the Nucleus Basalis of Meynert and Locus Coeruleus to Transentorhinal Cortex Tract [published online ahead of print, 2021 Dec 14].
Neurology.
2021;10.
1212/ WNL.
0000000000013206.
doi:10.
1212/WNL.
0000000000013206Leave

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