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The neuropathological features of Alzheimer's disease (AD) are amyloid plaques and neurofibrillary tangles
.
The accumulation of amyloid in the brain does not increase linearly with time; instead, this pattern is reminiscent of the multi-stage nucleation-dependent aggregation of amyloid β (Aβ) peptides in vitro
The neuropathological features of Alzheimer's disease (AD) are amyloid plaques and neurofibrillary tangles
Suzanne Schindler et al.
The research team used Pittsburgh compound B amyloid PET to measure brain amyloid load, and used longitudinal data to convert the average cortical standard uptake value ratio (SUVR) into a time scale
.
236 patients who underwent a PET scan of amyloid were assessed for amyloid accumulation
.
The average age was 66.
A critical point for amyloid accumulation is at a low level of amyloid load (SUVR 1.
2), after which almost all individuals accumulate amyloid at a relatively consistent rate until reaching a high level of amyloid load (SUVR 3.
0)
.
The average time between amyloid load levels is used to estimate the age at which an individual reaches SUVR 1.
Estimated age at which the individual reaches SUVR 1.
2
2
Observe the dementia syndrome over time and estimate the age when the symptoms appear
.
.
The longitudinal clinical diagnosis of 180 patients was consistent with the estimated age at SUVR 1.
2
.
In 22 individuals who progressed from cognitively normal to typical AD dementia syndrome, the estimated age at which the individual reached SUVR 1.
Diagnosis 2
The age of onset of sporadic AD is closely related to the age of reaching the critical point of amyloid accumulation
.
.
The age of onset of sporadic AD is closely related to the age of reaching the critical point of amyloid accumulation
Predicting Symptom Onset in Sporadic Alzheimer Disease With Amyloid PET.
Predicting Symptom Onset in Sporadic Alzheimer Disease With Amyloid PET.
https://n.
neurology.
org/content/97/18/e1823 https://n.
neurology.
org/content/97/18/e1823 https://n.
neurology.
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