Neurology: A study of 300,000 people revealed cancer incidence and mortality in people with multiple sclerosis

Cancer risk is increasingly being concerned about multiple sclerosis (MS).
between multiple sclerosis and cancer is complex, and several factors may change cancer risk in the opposite direction.
people with multiple sclerosis are more likely to exhibit healthy behaviors associated with an increased risk of cancer, such as smoking, lack of exercise and obesity;
the use of chronic immunosuppression as a follow-up to disease correction therapy (DMT) may also increase cancer risk;
2015, a systematic review found that cervical, breast and digestive cancers had the highest incidence of MS.
results on the relative risk of cancer in ms populations are not consistent.
many studies are not population-based or have other important limitations.
rate is critical to supporting drug alertness in DMT clinical trials, and can often only be compared to MS-specific incidence to determine whether the number of cancer cases is excessive.
published since 2014 continues to report different results on cancer risk in MS.
University of Canada and others, who used population-based data sources to compare the incidence of MS and matching queues and cancer-specific mortality rates, looked at whether cancer risk was different in patients with multiple sclerosis (MS) and non-MS patients.
conducted a retrospective matching queue study using population management data from Manitoba and Ontario, Canada.
to identify MS cases by applying an effective definition, and then select five control groups without MS to match in year of birth, gender, and region.
then linked the queues to the cancer registry and estimated the incidence of breast, colorectal and 13 other types of cancer.
for breast and colorectal cancer, Cox models were constructed to adjust the age of the onset date, socioeconomic status at the regional level, region, year of birth queue, and co-merger.
, the results of the provincial studies were summarized using meta-analysis.
results showed that a total of 53,983 MS cases and 269,1915 controls were included.
multivariable analysis showed no difference in breast cancer risk (HR=0.92) or colorectal cancer risk (HR=0.83) between the queues.
mortality rates from breast and colorectal cancer did not differ between the queues.
morbidity and mortality of bladder cancer in the MS queue.
although the incidence of prostate, uterine and central nervous system cancers varied between MS and the matching queue, there was no difference in mortality.
significance of this study is that there is no difference between those with and without MS, but the incidence of bladder cancer increases.
differences in the reported incidence of certain cancers in people with multiple sclerosis may reflect differences in diagnosis rather than real differences.
origins: Cancer Rates and Mortality Rates in Multiple Sclerosis-A Matched Cohort Study Ruth Ann Marrie, Colleen Maxwell, Alyson Mahar, Okechukwukuma, Chad McClintock, Dallas Seitz, Colleen Webber, Patti A. Groome Neurology Jan 2021, 96 (4) e501-e512; DOI: 10.1212/WNL.00000000000011219Freeman Source: MedSci Original Copyright Notice: All noted on this website "Source: Metz Medicine" or "Source: MedSci Original" text, images and audio and video materials, copyrights are owned by Metz Medical, without authorization, no media, website or individual may reproduce, authorized to reproduce with the words "Source: Mets Medicine".
all reprinted articles on this website are for the purpose of transmitting more information and clearly indicate the source and author, and media or individuals who do not wish to be reproduced may contact us and we will delete them immediately.
at the same time reproduced content does not represent the position of this site.
leave a message here