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NeuroImage: Resting-state fALFF and ReHo characterize metabolism

 Last Update: 2022-02-19
 Source: Internet
 Author: User

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rate analysis

oxygen blood

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Voxel-based physiological (VBP) variables extracted from blood oxygen level-dependent (BOLD) fMRI time course changes include: low frequency oscillatory amplitude (ALFF), low frequency oscillatory fractional amplitude (fALFF), and local consistency (ReHo)
.

Although these BOLD-derived variables can detect differences in spatial patterns between groups (eg, disease versus control), they have not been well explained physiologically

A related study by Peter T.
Fox et al.
quantified the spatial correspondence between the BOLD VBP variable and PET-measured cerebral metabolic rate and hemodynamics
.

Collection Schematic

Quantitative, whole-brain PET images of glucose metabolism rate (MRGlu; ¹⁸ FDG) and oxygen (MRO ₂ ; 15OO), blood flow (BF; H ₂¹⁵ O), and blood volume (BV) were collected from 16 healthy control subjects.
;C ¹⁵ O)
.

In the same subject, BOLD time series were obtained to calculate ALFF, fALFF and ReHo images

¹⁸₂₂¹⁵¹⁵

Spatial similarity of ALFF, ReHo, and PET hemodynamic metabolism
.

In population-averaged, cross-regional analysis, ALFF was only significantly associated with BV (R = 0.
64; p<0.
0001)
.

The correspondence between fALFF and MRGlu was the strongest (R = 0.

₂₂

Regions showing different regional contrasts in voxel-based BOLD-PET pairwise comparisons
.

Linear regression of BOLD metrics (ALFF, fALFF, and ReHo) and PET hemodynamic metabolism (BV, BF, MRO ₂ , and MRGlu)
.

₂

Conditional mutual information and interactive information analysis of BOLD index and PET hemodynamic metabolism
.

Under BV conditions, ALFF did not retain significant MRGlu, MRO ₂ and BF information
.

Under MRGlu conditions, fALFF and ReHo did not retain significant MRO2 _, BF or BV information

₂₂

This study details the cross-regional correlation of resting-state ALFF , fALFF , and ReHo with voxel-based hemodynamic and metabolic variables
.

This study provides strong evidence that the resting-state hemodynamic profile of voxel-based BOLD signaling reflects underlying metabolic demands .

This study details the cross-regional correlation of resting-state ALFF , fALFF , and ReHo with voxel-based hemodynamic and metabolic variables

Hemodynamic and metabolic correspondence of voxel-wise resting-state activity metrics in healthy adults

Hemodynamic and metabolic correspondence of voxel-wise resting-state activity metrics in healthy adults leave a message here

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