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Isoflurane is the most commonly used preclinical anesthetic, which can induce brain plasticity and long-term cellular and molecular changes, leading to behavioral and/or cognitive consequences.
To clarify the mechanism of isoflurane's long-term effects, this study investigated the effects of a single isoflurane exposure on functional connectivity, brain electrical activity, and gene expression.
Male Wistar rats (n=22) were exposed to 1.
The fMRI spectral power of the cortex (A) and hippocampus (B) in each isoflurane cycle.
The fMRI spectral power of the cortex (A) and hippocampus (B) in each isoflurane cycle.
Isoflurane treatment enhances the functional connection between thalamus-cortex and hippocampus-cortex.
Isoflurane treatment enhances the functional connection between thalamus-cortex and hippocampus-cortex.
The local field potential coherence between the right dentate gyrus and the right (A) or left (B) primary somatosensory cortex.
The local field potential coherence between the right dentate gyrus and the right (A) or left (B) primary somatosensory cortex.
Whether these changes are related to common behavioral and cognitive symptoms in patients and animals after surgery requires further research.
The study showed that long-term exposure to 1.
Prolonged exposure to 1.
Stenroos , Petteri et al.
Stenroos , Petteri et al.
“ Isoflurane affects brain functional connectivity in rats 1 month after exposure.
”NeuroImage , 117987.
21 Mar.
2021, doi:10.
1016/j.
neuroimage.
2021.
117987 Stenroos , Petteri et al.
“ Isoflurane affects brain functional connectivity in rats 1 month after exposure.
" NeuroImage leaves a message here
