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Neuro Oncol: MEK-1/2 inhibitor selumetinib significantly improves the prognosis of recurrent/progressive low-grade glioma in children

 Last Update: 2021-03-19
 Source: Internet
 Author: User

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Childhood low-grade gliomas (pLGGs) are the most common brain tumors in children .

Children's low-grade gliomas (pLGGs) are the most common brain tumors in children Children's low-grade gliomas (pLGGs) are the most common brain tumors inchildren

Recently, researchers have prioritized the functional prognosis of children with low-grade glioma.

This article reports the results of a PBTC Phase 2 trial in children with relapsed/progressive OPHGs, which evaluated the efficacy of the MEK-1/2 inhibitor selumetinib (selumetinib, AZD6244, ARRY-142886) in such patients.

A total of 25 evaluable patients with multiple conditions were included in the analysis, and the median number of previous treatment courses was 4 (1-11).

6 patients (24%) achieved partial remission, 14 (56%) had stable disease, 6 (24%) had partial remission, and 14 (56%) had stable disease.

The 2-year PFS is 78±8.

In summary, smetinib is well tolerated in children with relapsed/progressive OPHGs.

Sumetinib is well tolerated in children with relapsed/progressive OPHGs, and it can also improve imaging remission, PFS and visual prognosis, and prolong the stable period of disease.

Original source:

Fangusaro Jason, Onar-Thomas Arzu, Poussaint Tina Young et al.

oup.
com/neuro-oncology/advance-article-abstract/doi/10.
1093/neuonc/noab047/6149924?redirectedFrom=fulltext">A Phase 2 Trial of Selumetinib in Children with Recurrent Optic Pathway and Hypothalamic Low-Grade Glioma without NF1: A Pediatric Brain Tumor Consortium Study in this message

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