Neural Regen Res: Electroacupuncture can affect the pain sensation of nicotine-dependent hyperalgesia model rats

Nicotine dependence and chronic pain are very common in many societies
.
Both of these entities have a profound impact on public health and cause severe morbidity

.

Smokers have more painful areas, more severe pain, more severe physical and mental dysfunction, and require more intraoperative and postoperative narcotic analgesics than non-smokers

Compared with morphine, acupuncture analgesia is more efficient, faster, better tolerated One way to avoid chronic opioid dependence is acupuncture as a non-pharmacological interventions, effectively reduce the opioid requirements open EA The therapy is to pierce needle-like needles into acupoints of the human body and pass the electro-acupuncture treatment device with a pulse current of stable frequency.

The acupoint location of Zusanli (ST36) and Taichong (LR3) in rats:

However, there are few reports on the effect of acupuncture on pain sensitivity caused by long-term smoking

.

To study the influence of electric acupuncture on both sides of Zusanli (ST36) and Taichong (LR3)

The method is to establish a hyperalgesia model in rats exposed to nicotine for 6 weeks

.

The method is to display the results

The study shows that short-term exposure to nicotine has analgesic effects, and long-term exposure to nicotine can increase pain sensitivity
.
These findings are consistent with previous studies and other studies

.

Short-term exposure to nicotine has an analgesic effect, and long-term exposure to nicotine will increase pain sensitivity.

The results of the study showed that the expression of MOR, β-EP, GAD67 and GAD65 protein in the spinal cord of hyperalgesic rats induced by nicotine was significantly reduced

.

After electroacupuncture treatment, the expression of MOR, β-EP, GAD67 and GAD65 protein in the spinal cord of the same group of rats increased

According to this experiment, electroacupuncture seems to improve the pain sensitivity of hyperalgesic rats caused by nicotine

.
The possible mechanism for the positive effects of electroacupuncture seems to be related to the release of β-EP and the increase of MOR expression in the spinal cord and midbrain PAG
.
The increased β-EP combined with the increased MOR produces enhanced analgesia
.
Electroacupuncture can also increase the expression of GAD67 and GAD65 in the spinal cord, increase the expression of GAD65 in the midbrain PAG, promote the release of GABA, and once again produce analgesic effects
.
It is not clear whether electroacupuncture will have a similar effect in improving the effect of human nicotine withdrawal
.
Electroacupuncture may be an effective auxiliary analgesic for chronic pain caused by long-term chronic nicotine exposure
.

The possible mechanism for the positive effect of electroacupuncture seems to be related to the release of β-EP and the increase of MOR expression in the spinal cord and midbrain PAG
.
Electroacupuncture can also increase the expression of GAD67 and GAD65 in the spinal cord, increase the expression of GAD65 in the midbrain PAG, promote the release of GABA, and once again produce analgesic effects
.
Electroacupuncture may be an effective auxiliary analgesic for chronic pain caused by long-term chronic nicotine exposure
.

Original: Wang SJ, Zhang YP, Candiotti KA.
Effects of electroacupuncture on pain sensation in a rat model of hyperalgesia with nicotine dependence.
Neural Regen Res 2022;17:905-10.
DOI: 10.
4103/1673-5374.
322477

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