Nervous system or causeSARS-CoV-2 to spread rapidly in the lungs!

, June 30, 2020 /PRNewswire/ -- With more than 10 million cases
of new coronapneumonia worldwide, scientists are racing around the world to find ways to combat the symptoms of new coronapneumoniaResearchers at the University of Texas at Dallas recently identified a potential strategy for dealing with an accelerated worsening of lung disease14 scientists from the Center for Advanced Pain Research ,CAPS were involved in a project to determine whether lung problems associated with SARS-CoV-2 originated in the nervous systemSARS-CoV-2 is a coronavirus that can cause COVID-19their recent study, published online in the journal Brain, Behavior, and Immunity, found that interactions between the immune system and the nerves in the lungs can lead to rapid deterioration of COVID-19 patientsSome of these interactions may be offset by existing drugspicture source: It is widely believed that severe CASES OF COVID-19 may have a major inflammatory factor that appears to start in the lungs and then affect other parts of the bodyThe CAPS team analyzed open data from patients in China and studied the process as a potential case of neurogenic inflammation, in which the immune system and nervous system interact to form a vicious circle that causes inflammation to spiral out of control"Most people, even biomedical researchers, don't fully realize how much the nervous system interacts with each organ of the body," said DrTed Price, the study's lead author and head of CAPS"When you get sick, the way the immune system interacts with the nervous system is very important for the outcome of the diseaseThe more we know this, the more we can make sure that the patient is not too ill to live in the ICU and breathe on a ventilatorEugene McDermott, a professor of neuroscience at theCytokine Storm, explained that patients with severe COVID-19 conditions suffer mainly from acute respiratory distress syndrome syndrome "These people don't get enough air from their breath to fill their blood with oxygen, which makes them very weak," Price said Some need respirators; in March, when Price began the study, there was still a lack of knowledge about the disease But it has been pointed out that ARDS patients experience so-called "cytokine storms" in which the body quickly releases too many cytokines Dr Michael Burton, an assistant professor at BBS and a co-author of the study, said the diversity of these interactions was not understood until recently the mainstream idea of "neuro
immunology
was that immune cells influence behavior by signaling sensory neurons," said Burton, whose research focuses on how the immune system and nervous system interact Recent studies have shown that the opposite is true: sensory neurons communicate with immune cells to control the immune response Pathogens can also interact directly with sensory neurons for their own purposes, such as tuberculosis and sensory neurons, which trigger coughing, spreading and surviving "
Burton says this could be a key context for ardS's COVID-19 immune response "Many therapies are aimed at the immune cells themselves to suppress cytokine storms, " he said But evidence from our study suggests that it is linked to the interaction of neurons, immune cells, and other cells in the lungs, and may provide a new targeted treatment strategy Dr Pradipta Ray, a research scientist at the Key Protein BBS research scientist, is the first author of the paper, and he directs the creation of a computational method to examine how these nerve cells and immune cells react "We have performed molecular mapping analysis of the back root nerve clots (peripheral nerve cells that dominate the lungs) and the immune cells of the lungs in patients with COVID-19 in China," Price said Since scientists have published a paper, the maps have been made public So we combine the two kinds of information to study how immune cells interact with nerve cells, creating what we call interactions The results are very interesting "
in addition to the expected release of large amounts of cytokines to interact directly with neurons, the presence of a particular protein also caught the attention of the team "there has been a significant increase in NMDA (N-methyl-D-Tianmen) receptors in lung immune cells, which is very different from what you see in other diseases," Price said "This suggests that it is possible that neurons there can communicate with immune cells through glutamate, which is the neurotransmitter of the NMDA receptor Interrupting this interaction may reduce the devastating effect "
the participation of NMDA receptors is important because there are already drugs that can stop them Photo Source: Researchers say there is an opportunity to conduct clinical trials of rheumatoid arthritis drugs being developed or existing to treat high-risk or severe CASES of COVID-19 "We already have antagonists for NMDA receptors, so we have some drugs that might block this neurogenic inflammation," Price said However, these drugs may need to be used together for treatment, because the root cause is not just a simple molecule, but involves the entire host "
While researchers have confirmed that neuroimmune responses are a way for the most severe cases of COVID-19 to get out of hand, Price urges caution and says more research is needed to determine whether their views may be helpful to patients." "Our study shows that, in theory, the neuroimmune process can play a huge role, and we show how it works." But we still don't know to what extent neurogenic inflammation causes the disease The science of COVID-19 has moved so fast; we know the disease very quickly I'm confident that we'll know soon if our work will have an impact " (BioValleyBioon.com) reference: Pain researchers may know what COVID-19 spreads quickly in patients' lungs Pradipta R Ray et al A neuical ome ome covid-19 patient samples and human sensory s neurons sydd s ei drivers of the neurogenic pulmonary dysfunction, Brain, Behavior, and Ii (2020) DOI: 10.1016/j.bbi.2020.05.078
The brain may be a new therapeutic target for improving breathing leolung oedy in COVID-19
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