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NEJM: The effect of Daprodustat in the treatment of anemia in non-dialysis patients with chronic kidney disease

 Last Update: 2021-12-01
 Source: Internet
 Author: User

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Daprodustat is an oral hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI), which has been approved for the treatment of renal anemia caused by chronic kidney disease (CKD)

This was a randomized, open-label, to heart blood vessels outcomes Phase 3 clinical trials blind trial comparing the da orlistat and Afadabei Park (Darbepoetin alfa) not receiving dialysis treatment efficacy in patients with anemia of CKD

Heart blood vessel myocardial infarction, stroke

Changes in hemoglobin levels in the two groups

Overall, a total of 3872 patients were randomly divided into two groups and received daprestat or alfadabepo treatment

The mean (±SE) changes in hemoglobin levels in the daprestat group and afadabebo group from baseline to week 28 to week 52 were 0.

Cumulative incidence of MACE events in the two groups

After a median follow-up of 1.

In short, in patients with chronic kidney disease with anemia who have not undergone dialysis treatment, the effect of daprestat is not inferior to that of afadabepo in terms of changes in hemoglobin levels and cardiovascular outcomes

In chronic kidney disease patients with anemia who have not undergone dialysis treatment, in terms of changes in hemoglobin levels and cardiovascular outcomes, the effect of daprestat is not inferior to that of afadabepor in chronic anemia patients who have not undergone dialysis treatment.

Original source:

Singh Ajay K,Carroll Kevin,McMurray John JV et al.

Daprodustat for the Treatment of Anemia in Patients Not Undergoing Dialysis

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